A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-significant and significant fibrosis in patients with chronic hepatitis C

Shiha, Gamal; Seif, Seham; Eldesoky, Ayman; Elbasiony, Mohamed; Soliman, Reham; Metwally, Ammal M.; Zalata, Khaled; Mikhail, Nabiel

doi:10.1007/s12072-017-9796-z

Cited by 16 publications

(19 citation statements)

References 34 publications

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“…PPV was in the range of 24%–80% as against 50% in the current study. Similarly, NPV was in the range of 75.3%–98% compared with 90.24% in this study 17 20–25 29. As compared with previous studies, FIB-4 was not helpful for the prediction of SF in our study.…”

Section: Discussioncontrasting

confidence: 78%

“…PPV was 85.7% and 99% as against 18.75% (at cut-off ≥7.505) and 37.5% (at cut-off <0) in the current study. Similarly, NPV was 38.7% and 92% compared with 89.47% (at cut-off <0) and 90% (at cut-off ≥7.505) in this study 16 17. In our study, FIB-5 did not perform better as compared with previous studies.…”

Section: Discussioncontrasting

confidence: 56%

“…The serum scores were compared with the liver biopsy METAVIR scores and the area under the receiver operating characteristic curve (AUROC) for APRI, FIB-4 and FIB-5 was calculated. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of each of these scores using previously published cut-offs were calculated 14 16–18…”

Section: Methodsmentioning

confidence: 99%

“…Attallah et al developed FIB-5 score, which is based on three biochemical markers (AST/ALT ratio, albumin, alkaline phosphatase (ALP)) and one haematological marker (platelet count). The score was validated on 604 patients with chronic HCV 16 17. Application of FIB-5 in NAFLD has not been studied previously.…”

Section: Introductionmentioning

confidence: 99%

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Aspartate transaminase to platelet ratio index (APRI) but not FIB-5 or FIB-4 is accurate in ruling out significant fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in an urban slum-dwelling population

Kolhe

Amarapurkar

Parikh

et al. 2019

BMJ Open Gastroenterol

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Background and aimsNon-invasive assessment of fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) is challenging, especially in resource-limited settings. MR or transient elastography and many patented serum scores are costly and not widely available. There are limited data on accuracy of serum-based fibrosis scores in urban slum-dwelling population, which is a unique group due to its dietary habits and socioeconomic environment. We did this study to compare the accuracy of serum-based fibrosis scores to rule out significant fibrosis (SF) in this population.MethodsHistological and clinical data of 100 consecutive urban slum-dwelling patients with NAFLD were analysed. Institutional ethics committee permission was taken. Aspartate transaminase (AST) to platelet ratio index (APRI), fibrosis-4 index (FIB-4) and FIB-5 scores were compared among those with non-significant fibrosis (METAVIR; F0 to F1; n=73) and SF (METAVIR; F2 to F4; n=27).ResultsAST (IU/mL) (68.3±45.2 vs 23.9±10.9; p<0.0001), alanine transaminase (IU/mL) (76.4±36.8 vs 27.9±11.4; p<0.0001), FIB-4 (2.40±2.13 vs 0.85±0.52; p<0.0001) and APRI (1.18±0.92 vs 0.25±0.16; p<0.0001) were higher and platelets (100 000/mm3) (1.8±0.8 vs 2.6±0.7; p<0.0001), albumin (g/dL) (3.4±0.50 vs 3.7±0.4; p<0.0001), alkaline phosphatase (IU/L) (60.9±10.2 vs 76.4±12.9; p<0.0001) and FIB-5 (−1.10±6.58 vs 3.79±4.25; p<0.0001) were lower in SF group. APRI had the best accuracy (area under the receiver operating characteristic curve=0.95) followed by FIB-4 (0.78) and FIB-5 (0.75) in ruling out SF.ConclusionsAPRI but not FIB-5 or FIB-4 is accurate in ruling out SF in patients with NAFLD in an urban slum-dwelling population.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussioncontrasting

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aspartate transaminase to platelet ratio index (APRI) but not FIB-5 or FIB-4 is accurate in ruling out significant fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in an urban slum-dwelling population

Kolhe

Amarapurkar

Parikh

et al. 2019

BMJ Open Gastroenterol

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“…Hepatitis C is the most public health stress in Egypt where HCV prevalence is the highest in the world. Egypt Health Issues Survey (2015) showed that between 15 and 59 years of age, about 10% of Egyptians had been infected with HCV infection, while 7% of them have chronic active hepatitis C [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum protein markers in diagnosis of hepatocellular carcinoma and carcinogenesis risk assessment in chronic liver disease patients

Hegazy¹,

Eissa²,

Sorour³

et al. 2017

APJTD

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Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C

Huttman,

Parigi,

Zoncapè

et al. 2024

Cochrane Database of Systematic Reviews

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A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-significant and significant fibrosis in patients with chronic hepatitis C

Abstract: FIB-5 score at the new cutoff is superior to FIB-4 index for the differentiation between non-significant and significant fibrosis.

Cited by 16 publications

References 34 publications

Aspartate transaminase to platelet ratio index (APRI) but not FIB-5 or FIB-4 is accurate in ruling out significant fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in an urban slum-dwelling population

Aspartate transaminase to platelet ratio index (APRI) but not FIB-5 or FIB-4 is accurate in ruling out significant fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in an urban slum-dwelling population

Evaluation of serum protein markers in diagnosis of hepatocellular carcinoma and carcinogenesis risk assessment in chronic liver disease patients

Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C

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