A simple, convenient, and one pot synthetic route for the preparation of 1,3,5-thiadiazines-2-thione heterocyclic compounds and their antifungal activity

Saeed, Sohail

doi:10.1080/23312009.2015.1054554

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Earlier THTT was produced from amines, CS 2 , formaldehyde using inorganic base [23][24][25] . A number of PTC is frequently used for the synthesis of THTT 26 . On comparing the reaction condition it was comprehended that by using Triton-B, % yields of preferred product is improved than other types of PTC.17 Triton-B give 95% yield of THTT A range of 1o amines (aliphatic, alicyclic, heterocyclic, aromatic) and formaldehyde using Triton-B/CS 2 method at r.t led to formation of product THTT in excellent yields, "Table 1 Hz, 2H), 0.943 (t, J = 7.2Hz, 3H).…”

Section: Resultsmentioning

confidence: 99%

Triton-B Mediated One-Pot Multicomponent Synthesis of 3,5 Substituted Tetrahydro-2H-1,3,5-Thidiazine-2-Thiones

Kishore

Kamboj

Shukla³

2018

Orient. J. Chem

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A new-fangled, proficient, one-pot multi component, intramolecular C-S bond formation reaction, mediated by phase transfer catalyst, Triton-B, is described in this paper. The reaction of alkyl/ phenyl amines, CS2 and formaldehyde catalyzed via Triton-B resulted in formation of 3-(Alkyl or aryl methyl),5-(Alkyl or aryl methyl) substituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones compounds(1a-15a). These compounds (1a-15a) were characterized with the help of elemental analysis, IR, NMR and mass spectroscopic methods. The PTC mediated reactions require mild reaction condition and reduced time period for completion. The reaction is achieved at normal temperature under solvent free conditions with good yields and great selectivity. This methodology discourages the traditional synthesis method of inorganic base for such coupling reaction.

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