A simple route for the synthesis of novel $$N$$ -alkyl-2-(alkylthio)-1 $$H$$ -imidazole derivatives

Abstract

Novel N-alkyl-2-(alkylthio)-1H-imidazole derivatives were synthesized in a single step by an efficient and simple method in high yields. Readily available starting materials, mild reaction conditions, operational simplicity and novelty are the key advantages of this method. Besides their novel structures, these compounds may have important biological activities and industrial applications.

Ultrasound-promoted green approach for the synthesis of multisubstituted pyridines using stable and reusable SBA-15@ADMPT/H5PW10V2O40nanocatalyst at room temperature

“…Thus, the development of an eco-friendly and practical synthetic route for the efficient preparation of these pyridine derivatives will be a beneficial and interesting challenge. As part of our ongoing research program on the development of efficient methods for the preparation of biologically active compounds (43)(44)(45)(46)(47)(48), herein, we are going to report an efficient method for the synthesis of 2-amino-3-cyanopyridins under ultrasound waves. In this approach, the SBA-15@ADMPT/H 5 PW 10 V 2 O 40 was used as a highly efficient catalyst for the synthesis of highly substituted pyridines 3 via one-pot, four-component condensation reaction of aromatic aldehydes 1, cyclic ketones 2, ammonium acetate, and malononitrile at room temperature under ultrasound irradiation (Scheme 1).…”

Fe3O4@SiO2@ADMPT/H6P2W18O62: a novel Wells–Dawson heteropolyacid-based magnetic inorganic–organic nanohybrid material as potent Lewis acid catalyst for the efficient synthesis of 1,4-dihydopyridines

“…As part of our current studies on the development of efficient methods for the preparation of biologically active compounds (36)(37)(38)(39)(40)(41)(42)(43)(44), in this paper, Fe 3 O 4 @SiO 2 @ADMPT/H 6 P 2 W 18 O 62 as a new inorganic-organic hybrid nanocatalyst was prepared, characterized, and used as an effective catalyst in the synthesis of 1,4-DHPs 4 via one-pot reaction of various aromatic aldehydes 1, ethyl acetoacetate 2, and ammonium acetate 3 with good to high yield in ethanol (Scheme 1). To the best of our knowledge, there are no examples of the use of WD HPAs as the catalyst for the synthesis of 1,4-DHP derivatives.…”

Direct synthesis of benzo[a]carbazoles by palladium-catalyzed domino reactions: synthesis and photophysical properties of diverse benzo[a]carbazoles

“…In modern organic chemistry, both tandem reactions and C-H functionalization are considered as efficient tools for the synthesis of complex molecules in terms of atom economy. As part of our ongoing research program on the development of efficient methods in organic synthesis and on the preparation of heterocyclic compounds [41][42][43][44][45][46], to develop a more atom economical and direct …”