A simple way to synthesize well-dispersed Gd2O3 nanoparticles onto reduced graphene oxide sheets

Yang, Shengsheng; Gao, Hui; Wang, Yunfei; Xin, Shuangyu; He, Yongming; Wang, Yanzhao; Zeng, Wei

doi:10.1016/j.materresbull.2012.09.065

Cited by 14 publications

(9 citation statements)

References 25 publications

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“…531.8 eV, respectively, along with Gd 3d (1187.6 eV) representing that the Gd ions were in (III) state in the sample. 32,33 The composition of Gd/As for the sample was found to be 1:1.39 on the surface.…”

Section: ■ Results and Discussionmentioning

confidence: 93%

“…Gd-AsNDs were prepared by a solvothermal method inspired by a self-delivery system based on an inorganic phosphate-triggered release of anticancer ATO. , Briefly, 0.5 mmol of gadolinium(III) 2,4-pentanedionate hydrate and 0.5 mmol of sodium arsenite were dispersed with a methanol/DMF solution (2:1) cosolvent and 2 mL of water under constant stirring. The mixture was moved into a Teflon-lined autoclave and kept at 180 °C for reaction for 24 h. Subsequently, arsenic (As) was coprecipitated to form Gd-AsNDs when kept aside to cool at room temperature.…”

Section: Methodsmentioning

confidence: 99%

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Integrin α_vβ₃ Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Khatik

Wang

Zhi

et al. 2019

ACS Appl. Mater. Interfaces

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Multifunctional nanomaterials with targeted imaging and chemotherapy have high demand with great challenge. Herein, we rationally aimed to design multifunctional drug delivery systems by RGD-modified chitosan (CH)-coated nanoneedles (NDs) of gadolinium arsenate (RGD-CH-Gd-AsNDs). These NDs have multifunctionality for imaging and targeted therapy. NDs on intravenous administration demonstrated significant accumulation of As ions/species in tumor tissues, which was monitored by the change in T 1 -weighted magnetic resonance (MR) imaging. Moreover, NDs were well opsonized in cells with high specificity, subsequently inducing apoptosis to the HepG2 cells. Consequent to this, the in vivo results demonstrated biosafety, enhanced tumor targeting, and tumor regression in a subcutaneously transplanted xenograft model in nude mice. These RGD-CH-Gd-AsNDs have great potential, and we anticipate that they could serve as a novel platform for real-time T 1weighted MR diagnosis and chemotherapy. KEYWORDS: chitosan-coated nanoneedles of gadolinium arsenate (CH-Gd-AsNDs), arginylglycylaspartic acid (Arg-Gly-Asp or RGD) peptide-conjugated CH-Gd-AsNDs, magnetic resonance imaging, α v β 3 integrin receptor, tumor imaging, cancer therapy

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Section: ■ Results and Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Integrin α_vβ₃ Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Khatik

Wang

Zhi

et al. 2019

ACS Appl. Mater. Interfaces

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“…It was then dried in hot air oven and calcined at 700 °C for 4 h in Ar to obtain crystalline Gd 2 O 3 nanoparticles on the rGO sheet. 19 An inert environment was chosen for calcination to avoid the oxidation of rGO. 2.4.…”

Section: Methodsmentioning

confidence: 99%

“…19−22 It has been reported as one of the potential candidates as the contrast agent for application in magnetic resonance imaging. 19,23,24 Moreover, Gd 2 O 3 serve as the host material and can easily be doped with other rare earth ions (such as Eu 3+ , Ce 3+ , Tb 3+ , Yb 3+ , and Er 3+ ). 19 Lanthanide ion-doped Gd(OH) 3 and Gd 2 O 3 have also been studied for applications in displays and fluorescence imaging.…”

Section: Introductionmentioning

confidence: 99%

“…19,23,24 Moreover, Gd 2 O 3 serve as the host material and can easily be doped with other rare earth ions (such as Eu 3+ , Ce 3+ , Tb 3+ , Yb 3+ , and Er 3+ ). 19 Lanthanide ion-doped Gd(OH) 3 and Gd 2 O 3 have also been studied for applications in displays and fluorescence imaging. 23 Especially, cubic Gd 2 O 3 :Eu 3+ has wide applications in X-ray scintillator, high-definition projection televisions, flat panel displays, and photoelectronic apparatus, owing to its good luminescent properties when doped with rare-earth ions (Eu 3+ , Tb 3+ ).…”

Section: Introductionmentioning

confidence: 99%

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Mechanistic Insight into the Nature of Dopants in Graphene Derivatives Influencing Electromagnetic Interference Shielding Properties in Hybrid Polymer Nanocomposites

Sushmita¹,

Menon²,

Sharma

et al. 2019

J. Phys. Chem. C

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The recent surge in the usage of electronics has led to a new kind of problem; electromagnetic interference which necessitates finding alternate materials that offer ease of processing, design flexibility, light weight, and ease of embedding and integrating with the existing systems in place as shields to protect the precise electronic circuitry. Herein, lightweight polycarbonate (PC)-based nanocomposites using doped graphene derivatives and multiwalled carbon nanotubes (MWCNT) has been explored for effective shielding of EM radiation in X- and Ku-band. To get a mechanistic insight as to how the dopant in graphene derivatives influences the EM shielding properties, two dopants have been explored here: ferrimagnetic (ferrite, Fe3O4) and the other one as paramagnetic (gadolinium oxide, Gd2O3). The doped graphene derivatives when composited with PC and MWCNTs resulted in materials that can shield the incoming EM radiation through magnetic and dielectric losses. This strategy of doping improves the state of dispersion of these dopants in the nanocomposites, besides enhancing the shielding effectiveness. The PC-based nanocomposites illustrated a total shielding effectiveness (SET) of −28 and −33 dB at 18 GHz for a given concentration of Gd2O3 and Fe3O4 hybrid, respectively. A closer look into the mechanism of shielding reveals that irrespective of the dopant, various losses (magnetic and dielectric) decide the shielding effectiveness in polymeric nanocomposites facilitated by multiple internal reflections. Taken together, this study brings in new insight as to how the losses contribute toward effective shielding rather than the choice of the dopant and will help guide researchers working in this area from both industrial as well as academic perspective.

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Green Synthesis of Sub‐10 nm Gadolinium‐Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor‐Bearing Mice in Magnetic Resonance Imaging

Zhang

Yang

et al. 2016

Adv Healthcare Materials

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Gadolinium (Gd)-based nanoparticles are known for their high potential in magnetic resonance imaging (MRI). However, further MRI applications of these nanoparticles are hampered by their relatively large sizes resulting in poor organ/tumor targeting. In this study, ultrafine sub-10 nm and biocompatible Gd-based nanoparticles are synthesized in a bioinspired, environmentally benign, and straightforward fashion. This novel green synthetic strategy is developed for growing dextran-coated Gd-based nanoparticles (GdNPs@Dex). The as-prepared GdNPs@Dex is not only biocompatible but also stable with a sub-10 nm size. It exhibits higher longitudinal and transverse relaxivities in water (r and r values of 5.43 and 7.502 s × 10 m of Gd , respectively) than those measured for Gd-DTPA solution (r and r values of 3.42 and 3.86 s × 10 m of Gd , respectively). In vivo dynamic T -weighted MRI in tumor-bearing mice shows GdNPs@Dex can selectively target kidneys and tumor, in addition to liver and spleen. GdNPs@Dex is found particularly capable for determining the tumor boundary with clearly enhanced tumor angiogenesis. GdNPs@Dex is also found cleared from body gradually mainly via hepatobiliary and renal processing with no obvious systemic toxicity. With this green synthesis strategy, the sub-10 nm GdNPs@Dex presents promising potentials for translational biomedical imaging applications.

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A simple way to synthesize well-dispersed Gd2O3 nanoparticles onto reduced graphene oxide sheets

Cited by 14 publications

References 25 publications

Integrin α_vβ₃ Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Integrin α_vβ₃ Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Mechanistic Insight into the Nature of Dopants in Graphene Derivatives Influencing Electromagnetic Interference Shielding Properties in Hybrid Polymer Nanocomposites

Green Synthesis of Sub‐10 nm Gadolinium‐Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor‐Bearing Mice in Magnetic Resonance Imaging

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A simple way to synthesize well-dispersed Gd2O3 nanoparticles onto reduced graphene oxide sheets

Cited by 14 publications

References 25 publications

Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Mechanistic Insight into the Nature of Dopants in Graphene Derivatives Influencing Electromagnetic Interference Shielding Properties in Hybrid Polymer Nanocomposites

Green Synthesis of Sub‐10 nm Gadolinium‐Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor‐Bearing Mice in Magnetic Resonance Imaging

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Product

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Integrin α_vβ₃ Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

Integrin α_vβ₃ Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy