A Simplified Review on Microsphere and Their Different Applications

Abstract

Microspheres are small free-flowing particles with 1-1000um diameter and can be used to overcome the problems of conventional drug delivery. By altering the materials, methods, and polymers the therapeutic efficacy of microspheres containing drug content can be altered. We have discussed about microspheres, their various types, techniques used to manufacture microspheres, also about the advantages and different application of microsphere. Microspheres are used in novel drug delivery system. The microsphere will be assessed using a variety of procedures to determine its quality. Microspheres will play an important role in the delivery of novel medication in the future. Microspheres use in treatment of different disease conditions.

Modeling of in vitro drug release from polymeric microparticle carriers

“…The properties of the polymer significantly affect the site, mechanism and kinetics of drug release from the carrier. Two main mechanisms of drug release from the microspheres have been described: (a) the drug's diffusion and/or dissolution from the swellable or non-swellable polymer matrix, and (b) the drug's diffusion and/or dissolution governed by the erosion or dissolution of the polymer (22)(23)(24)(25)(26). The release of the drug substance from the biodegradable microspheres is a consequence of the gradual decomposition (bioerosion) of the polymer matrix, typically by hydrolysis or enzymatic degradation.…”