A single amino acid substitution in the H-2Kb molecule generates a defined allogeneic epitope

Kesari, Krishna V.; Bleek, Grada van; Nathenson, Stanley G.; Geliebter, Jan

doi:10.1016/0161-5890(93)90441-d

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1999

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“…However, these findings are insufficient to conclude that all, even most, alloreactivity is peptide‐specific. In addition to our previous work with primary mixed lymphocyte reaction (MLR) alloreactive T‐cell populations [16], there are several reports of alloreactive T‐cell clones that do not show evidence of peptide specificity [17–21].…”

Section: Introductionmentioning

confidence: 99%

Alloreactive Cytotoxic T‐Cell Function, Peptide Nonspecific

et al. 1999

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The recognition requirements necessary for murine alloreactive cytotoxic T-cells to carry out their effector function has been investigated using target cells that express a unique class I major histocompatibility complex (MHC)-peptide pair. The human cell line T2 and the murine cell line RMA-S are defective in peptide transport components needed to effectively express stable MHC class I molecules at the cell surface. When T2 cells were infected with a vaccinia virus that encoded the

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Section: Introductionmentioning

confidence: 99%