2022
DOI: 10.1101/2022.09.30.510346
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A single-cell multi-omic atlas spanning the adult rhesus macaque brain

Abstract: Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. Altogether, we profiled 2.58M transcriptomes and 1.59M epigenomes from single nuclei sampled from 30 regions across the adult brain. Cell composition differed extensively across the brain, revealing cellular signatures of region-specific functions. We also identified 1.19M can… Show more

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Cited by 4 publications
(5 citation statements)
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“…3B), which were largely conserved between the two NHPs and mice. We also observed proportionally fewer neuronal nuclei in both NHP atlases compared to the mouse atlas, consistent with previous reports ( 38–43 ).…”
Section: Resultssupporting
confidence: 92%
“…3B), which were largely conserved between the two NHPs and mice. We also observed proportionally fewer neuronal nuclei in both NHP atlases compared to the mouse atlas, consistent with previous reports ( 38–43 ).…”
Section: Resultssupporting
confidence: 92%
“…The first key finding in this study is that the GABAergic cell types are well conserved between areas V1 and V4, in line with studies from multiple other primates [8,17,[27][28][29].…”
Section: Discussionsupporting
confidence: 86%
“…The first key finding in this study is that the GABAergic cell types are well conserved between areas V1 and V4, in line with studies from multiple other primates [8, 17, 27–29]. PVALB+ GABAergic neurons have been reported to be enriched in the occipital lobe of marmosets [29, 30], macaques [28] and humans [11].…”
Section: Discussionsupporting
confidence: 85%
“…Clearly, additional cell-specific transcriptomic experiments are needed to gather in-depth information on the expression patterns of the key conductances in BLA-projecting cholinergic neurons in mouse and macaque. Patch-seq, combining electrophysiological recordings with single-cell transcriptome profiling in the same cells (Lipovsek et al, 2021;Chiou et al, 2023;Yao et al, 2023), would be especially useful.…”
Section: Potential Mechanisms Underlying Observed Physiological Diffe...mentioning
confidence: 99%