2024
DOI: 10.1002/adma.202410962
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A Single‐Cell RNA Sequencing Guided Multienzymatic Hydrogel Design for Self‐Regenerative Repair in Diabetic Mandibular Defects

Peihua Lin,
Zhouyang Qian,
Shanbiao Liu
et al.

Abstract: Conventional bone tissue engineering materials struggle to reinstate physiological bone remodeling in a diabetic context, primarily due to the compromised repolarization of proinflammatory macrophages to anti‐inflammatory macrophages. Here, leveraging single‐cell RNA sequencing (scRNA‐seq) technology, the pivotal role of nitric oxide (NO) and reactive oxygen species (ROS) is unveiled in impeding macrophage repolarization during physiological bone remodeling amidst diabetes. Guided by scRNA‐seq analysis, we eng… Show more

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