A single center experience in pediatric cardiomyopathy. Risk factors, outcomes and the effect of levosimendan

Kourelis, Georgios; Apostolopoulou, Sotiria C.; Rallis, Dimitrios; Vagenakis, Georgios; Kakava, Felicia; Kyriakoulis, Konstantinos G; Laskari, Cleo; Tsoutsinos, Alexandros; Ekmektzoglou, Konstantinos; Chalkias, Athanasios; Iacovidou, Nicoletta; Rammos, Spyridon

doi:10.1016/j.ppedcard.2020.101201

Cited by 1 publication

(1 citation statement)

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“…Besides genetic factors, inflammation, infection, immune dysfunction, endocrine, and metabolic abnormalities are also common pathogenic factors. In addition, cardiomyopathy in some patients is associated with tachycardia, abnormal protein deposition of myocardial interstitium, and left ventricular myocardial densification [ 16 , 17 ]. Cardiomyopathy has high mortality rates, but there are few reports on the analysis of risk factors for death in China.…”

Section: Discussionmentioning

confidence: 99%

Study on Risk Factors for Death from Cardiomyopathy and Effectiveness of Health Information Management

Wang

Zhang

Wang

et al. 2021

Journal of Healthcare Engineering

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Objective. To explore risk factors for death from cardiomyopathy and the effectiveness of health information management (HIM). Methods. A total of 80 patients with cardiomyopathy admitted in ICU of our hospital (January 2016–January 2020) were selected as study subjects, and the clinical data of the patients were retrospectively analyzed. The patients were divided into the survival group (n = 72) and the death group (n = 14) according to the treatment outcome. Then, according to the management mode, the survival group was further equally divided into the conventional group and the HIM group to investigate the influence of risk factors on prognosis of patients with cardiomyopathy and the effectiveness of HIM. Results. No significant difference was found in baseline body mass, myocardial enzymes, troponin, infection factors, history of heart disease, and gender between the survival group and the death group ( P > 0.05). Compared with the survival group, the patients of the death group were older ( P < 0.05), LVEF of the death group was obviously lower ( P < 0.05), and the scores of APACHE II and SOFA of the death group were obviously higher ( P < 0.05). Further logistic regression analysis of the univariate factors influencing the risk of death from cardiomyopathy led to the conclusion that LVEF was an independent risk factor for death in patients with cardiomyopathy. LVEF below 24.69% examined by echocardiography had a high predictive value, with a sensitivity of 98.6% and a specificity of 78.6%. No obvious difference was found in general data between the conventional group and the HIM group ( P > 0.05). Compared with the conventional group, the disease remission rate, complication rate, awareness rate of health knowledge, ICU length of stay, and scores of self-management efficacy of the HIM group were obviously better ( P < 0.05). No significant difference was found in 5-year mean survival rate between the conventional group and the HIM group ( P > 0.05). Conclusion. Older age, lower LVEF, and higher scores of APACHE II and SOFA are all risk factors for death from cardiomyopathy. Lower LVEF is an independent risk factor, and LVEF below 24.69% is an important indicator of increased risk of death. Moreover, HIM can effectively improve short-term treatment efficacy but has little effect on the long-term survival rate.

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Section: Discussionmentioning

confidence: 99%