A Single-Center Retrospective Descriptive Cohort Study of 211 Pediatric Patients: Cerebrospinal Fluid Leakage After Fourth Ventricle Tumor Resection

Kushel, Yury; Szostek, Małgorzata; Tekoev, A R; Chel'diev, B Z; Strunina, Yulia

doi:10.1016/j.wneu.2019.05.091

Cited by 7 publications

(11 citation statements)

References 13 publications

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“…In the pediatric population, specifically, the burden of additional treatment that may be required for CSF leakage or related complications is substantial. In studies reporting data on treatment of CSF leakage, a total of 37 out of 114 patients with a CSF leak were treated with a ventriculoperitoneal shunt [2,5,7,9,14,19,20,23,34,35]. There is a wide range of reported CSF leakage rates (between 0.0 and 38.0%) [6,12,17,28].…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid leakage after cranial surgery in the pediatric population—a systematic review and meta-analysis

et al. 2021

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Background Cerebrospinal fluid (CSF) leakage is a common complication after neurosurgical intervention. It is associated with substantial morbidity and increased healthcare costs. The current systematic review and meta-analysis aim to quantify the incidence of cerebrospinal fluid leakage in the pediatric population and identify its risk factors. Methods The authors followed the PRISMA guidelines. The Embase, PubMed, and Cochrane database were searched for studies reporting CSF leakage after intradural cranial surgery in patients up to 18 years old. Meta-analysis of incidences was performed using a generalized linear mixed model. Results Twenty-six articles were included in this systematic review. Data were retrieved of 2929 patients who underwent a total of 3034 intradural cranial surgeries. Surprisingly, only four of the included articles reported their definition of CSF leakage. The overall CSF leakage rate was 4.4% (95% CI 2.6 to 7.3%). The odds of CSF leakage were significantly greater for craniectomy as opposed to craniotomy (OR 4.7, 95% CI 1.7 to 13.4) and infratentorial as opposed to supratentorial surgery (OR 5.9, 95% CI 1.7 to 20.6). The odds of CSF leakage were significantly lower for duraplasty use versus no duraplasty (OR 0.41 95% CI 0.2 to 0.9). Conclusion The overall CSF leakage rate after intradural cranial surgery in the pediatric population is 4.4%. Risk factors are craniectomy and infratentorial surgery. Duraplasty use is negatively associated with CSF leak. We suggest defining a CSF leak as “leakage of CSF through the skin,” as an unambiguous definition is fundamental for future research.

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid leakage after cranial surgery in the pediatric population—a systematic review and meta-analysis

et al. 2021

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“…The incidence of CSF leakage in the analyzed series varied from 0 to 27% ( 2 , 6 , 22 – 24 , 26 , 47 ), and the incidence of postoperative meningitis was noted in 0.47% - 20% of the cases ( 2 , 6 , 22 , 26 ).…”

Section: Introductionmentioning

confidence: 94%

“…The most common tumor types in the IV ventricle and brainstem are medulloblastomas ( 2 , 10 , 15 , 21 – 26 ) (7–93.3%), metastases ( 2 , 3 , 21 , 25 , 27 , 28 ) (4.8–46.4%), ependymomas ( 2 , 3 , 9 , 15 , 21 – 30 ) (6.7–38%), astrocytomas (grade I–IV) ( 2 , 3 , 9 , 21 – 26 , 28 , 30 ) (7.3–33%), subependymomas ( 2 , 22 ) (9–19.5%), chorioidpapillomas ( 2 , 9 , 21 – 23 , 26 , 30 ) (2.2–14.6%), and hemangioblastomas ( 2 , 3 , 9 , 15 , 21 – 23 , 25 ) (4.9–14.3%).…”

Section: Introductionmentioning

confidence: 99%

“…and an increased risk of sinus damage. The authors prefer both resection ( 21 , 29 ) and osteoplastic ( 23 , 24 , 26 ) craniotomy. Both options have advantages and disadvantages; however, according to Gnanalingham’s study that compared the complications of craniotomy and craniectomy, the number of CSF leaks and pseudomeningoceles was significantly higher in the craniectomy group of patients (27 vs. 4% and 23 vs. 9%, respectively) ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…During the perioperative period, intraoperative air embolism occurred as a complications in 9.5% of patients who had surgery while sitting in the study by Gok et al ( 25 ). Symptomatic pneumocephalus was observed in two series of patients with an incidence of 4 and 0.95%, where the position of the patients was predominantly on their side and when sitting, respectively ( 2 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

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Fourth Ventricle Tumors: A Review of Series Treated With Microsurgical Technique

2022

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Tumors of the IV ventricle represent 1–5% of all intracranial lesions; they are implicated in 2/3 of the tumors of the ventricular system. According to modern standards, the first treatment stage for this pathology is microsurgical removal. Currently, for the removal of neoplasms of the IV ventricle and brainstem, the median suboccipital approach is widely used, followed by one of the microapproaches. Moreover, with the development of microsurgical techniques, keyhole approaches are now beginning to be utilized. However, surgical treatment of these tumors remains a challenge for neurosurgeons due to the proximity of functionally important anatomical structures (the brainstem, the cerebellum, pathways, vessels, etc.) of the posterior cranial fossa. Therefore, surgery in this area is associated with the possible occurrence of a wide range of postoperative complications. The authors provide a review of series of fourth ventricle tumors treated with microsurgical technique.

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Duraplasty with Cervical Fascia Autograft to Reduce Postoperative Complications of Posterior Fossa Tumor Surgery with Suboccipital Midline Approach

et al. 2020

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A Single-Center Retrospective Descriptive Cohort Study of 211 Pediatric Patients: Cerebrospinal Fluid Leakage After Fourth Ventricle Tumor Resection

Cited by 7 publications

References 13 publications

Cerebrospinal fluid leakage after cranial surgery in the pediatric population—a systematic review and meta-analysis

Cerebrospinal fluid leakage after cranial surgery in the pediatric population—a systematic review and meta-analysis

Fourth Ventricle Tumors: A Review of Series Treated With Microsurgical Technique

Duraplasty with Cervical Fascia Autograft to Reduce Postoperative Complications of Posterior Fossa Tumor Surgery with Suboccipital Midline Approach

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