A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats

Alexanderson, Camilla; Stener-Victorin, Elisabet; Kullberg, Joel; Nilsson, Staffan; Levin, Max; Cajander, Stefan; Lönn, Lars; Lönn, Malin; Holmäng, Agneta

doi:10.1016/j.jsbmb.2009.10.006

Cited by 19 publications

(20 citation statements)

References 86 publications

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“…These findings agree with other studies that have shown that treatment with testosterone or estradiol leads to anovulation and, consequently, the absence of corpora lutea (Mahamed et al, 2011;Barraclough, 1961;Alexanderson et al, 2010Alexanderson et al, , 2007Brawer et al, 1986). In the histological analysis, the ovaries presented with an increase in their theca-interstitial area and absence of corpora lutea.…”

Section: Cg Eg Tgsupporting

confidence: 91%

“…Previous studies have shown that androgen interferes with the ovulation process and might have a direct effect on the ovary (Sjaarda et al, 2014). On the other hand, estrogens are also able to induce anovulation and disrupt reproductive functions, but how it affects specific steps of the reproductive physiology is not well known (Alexanderson et al, 2010;Franks, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels

Marcondes¹,

Carvalho²,

Duarte³

et al. 2015

General and Comparative Endocrinology

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Section: Cg Eg Tgsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels

Marcondes¹,

Carvalho²,

Duarte³

et al. 2015

General and Comparative Endocrinology

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“…Recent studies have shown that 17 β -estradiol may play a role in reducing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems [28–30]. Further, various cell studies have indicated that sex hormones may play a role in the regulation of C3 [31], C5aR [32, 33], and the C5L2/ASP response [34]. …”

Section: Introductionmentioning

confidence: 99%

Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery

et al. 2014

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Objective. Obesity is associated with metabolic dysfunction with sex differences and chronic, low-grade inflammation. We proposed that hepatic expression of immune complement C3 related receptors (C3aR, C5aR, and C5L2) would be associated with pre- or postmenopausal status and metabolic profile in severely obese women. We hypothesized that C5L2/C5aR ratio, potentially influencing the ASP/C5L2 metabolic versus C5a/C5aR immune response, would predict metabolic profiles after weight loss surgery. Materials and Methods. Fasting plasma (hormone, lipid, and enzyme analysis) and liver biopsies (RT-PCR gene expression) were obtained from 91 women during surgery. Results. Hepatic C5L2 mRNA expression was elevated in pre- versus postmenopausal women (P < 0.01) and correlated positively with circulating estradiol, estrone, ApoB, ApoA1, ApoA1/B, waist circumference, age, and LDL-C (all P < 0.05). While plasma ASP was lower in pre- versus postmenopausal women (P < 0.01), the hepatic C5L2/C5aR mRNA ratio was increased (P < 0.001) and correlated positively with estrone (P < 0.01) and estradiol (P < 0.001) and negatively with circulating ApoB and liver enzymes ALT, AST, and GGT (all P < 0.05). Over 12 months postoperatively, liver enzymes in low C5L2/C5aR mRNA ratio group remained higher (ALP and ALT, P < 0.05, AST and GGT, P < 0.001 2-way-ANOVA). Conclusion. C5L2-C5aR association with other mediators including estrogens may contribute to hepatic metabolic and inflammatory function.

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“…Sex hormone programming in animals has also been shown to affect adipose tissue. A single postnatal injection of estradiol benzoate resulted in the development of IR, increased adipose tissue mass and adipocyte size in adult female rats, suggesting that postnatal ER activation exerts strong programming effects on metabolic processes (Alexanderson et al, 2010). Stromal cells from adipose tissue have been shown to locally produce estrogens (Simpson et al, 2009).…”

Section: Ers and The Role Of Adipose Tissue In Glucose Homeostasismentioning

confidence: 99%

Estrogen Receptors in Glucose Homeostasis

Faulds¹,

Dahlman-Wright²

2011

Update on Mechanisms of Hormone Action - Focus on Metabolism, Growth and Reproduction

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A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats

Cited by 19 publications

References 86 publications

Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels

Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels

Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery

Estrogen Receptors in Glucose Homeostasis

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