A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans

Charron, Craig S.; Dawson, Harry; Albaugh, George P.; Solverson, Patrick; Vinyard, Bryan T.; Solano‐Aguilar, Gloria; Molokin, Aleksey; Novotny, Janet A.

doi:10.3945/jn.115.215392

Cited by 43 publications

(25 citation statements)

References 69 publications

(67 reference statements)

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“…An immune enhancing effect of garlic was also confirmed in a randomized clinical trial with 17 volunteers who had a garlic-free or garlic-containing meal for 10 days. The trial showed that garlic can upregulate immune response genes and activate apoptosis and the xenobiotic metabolism in people who regularly consume garlic containing meals ( Charron et al, 2015 ). The anti-inflammatory and immunomodulatory potential of garlic was also subject to a most recent publication indicating that garlic may be beneficial as a preventive measure in the current COVID-19 pandemic ( Donma & Donma, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…Garlic are immune modulators and reports suggest dietary meal containing garlic (raw or crushed) can influence the expression of immunity in humans ( Abdullah, 2000 ; ( Charron et al, 2015 ). A recent clinical trial has shown that diet supplemented with aged garlic extract (AGE) can modulate the inflammation and immunity of adults with obesity ( Xu et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

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Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Rouf

Uddin

Sarker

et al. 2020

Trends in Food Science & Technology

209

140

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Background Garlic ( Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its antiviral effects and the underlying molecular mechanisms exists. Scope and approach The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. Key findings and conclusions Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Rouf

Uddin

Sarker

et al. 2020

Trends in Food Science & Technology

209

140

View full text Add to dashboard Cite

show abstract

“…Numerous mechanisms have been recommended to explain the chemo-preventive effects of garlic, including the inhibition of DNA adduct formation, the inhibition of mutagenesis by blocking metabolism, through its free-radical scavenging, or by decreasing cell proliferation and tumor growth [ 74 ]. In this context, Charron et al [ 76 ] performed a clinical trial on gene expression related to immunity, apoptosis, and xenobiotic metabolism in humans, after consumption of 5 g raw, crushed garlic daily for 10 days. A single meal containing raw crushed garlic activated the expression of seven genes, such as activating protein with immunoreceptor tyrosine-based activation motif 1, aryl hydrocarbon receptor nuclear translocator, aryl hydrocarbon receptor, hypoxia-inducible factor 1α, c-Jun, nuclear factor of activated T cells, oncostatin M and V-rel avian reticuloendotheliosis viral oncogene homolog in blood of healthy volunteers, thus inhibiting tumorigenesis.…”

Section: Clinical Trials On Garlicmentioning

confidence: 99%

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

et al. 2020

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Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.

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“…The allyl mercaptan with the best histone deacetylase inhibitor from garlic revealed its anticancer mechanisms [ 61 ]; however Z-ajoene from garlic can be treated the glioblastoma by targeting its cancer stem cells [ 62 ]. Garlic intake is negatively associated with the cancer and cardiovascular disease, based on activation of genes with immunity, apoptosis, and xenobiotic metabolism [ 110 ].…”

Section: Chronic Disease Prevention Of Allium Gmentioning

confidence: 99%

Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being

Zeng

Yang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

109

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Objectives. Functional components in alliums have long been maintained to play a key role in modifying the major risk factors for chronic disease. To obtain a better understanding of alliums for chronic disease prevention, we conducted a systematic review for risk factors and prevention strategies for chronic disease of functional components in alliums, based on a comprehensive English literature search that was conducted using various electronic search databases, especially the PubMed, ISI Web of Science, and CNKI for the period 2007–2016. Allium genus especially garlic, onion, and Chinese chive is rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer, preventive cardiovascular and heart diseases, anti-inflammation, antiobesity, antidiabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, and so on. These results support Allium genus; garlic and onion especially may be the promising dietotherapeutic vegetables and organopolysulfides as well as quercetin mechanism in the treatment of chronic diseases. This review may be used as scientific basis for the development of functional food, nutraceuticals, and alternative drugs to improve the chronic diseases.

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A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans

Abstract: These data indicate that the bioactivity of garlic is multifaceted and includes activation of genes related to immunity, apoptosis, and xenobiotic metabolism in humans and Mono Mac 6 cells. This trial is registered at clinicaltrials.gov as NCT01293591.

Cited by 43 publications

References 69 publications

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being

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