A single nucleotide polymorphism of the apolipoprotein A–V gene −1131T&gt;C modulates postprandial lipoprotein metabolism

Moreno, Rafael Cantón; Pérez-Jiménez, Francisco; Marı́n, Carmen; Moreno, Juan Antonio; Gomez, Purificación; Bellido, C.; Pérez‐Martínez, Pablo; Jiménez‐Gómez, Yolanda; Fuentes, Francisco; López‐Miranda, José

doi:10.1016/j.atherosclerosis.2005.11.029

Cited by 30 publications

(25 citation statements)

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“…Although the magnitude of the genetic effect on variation in the postprandial lipid response is unknown, each of these genes seems to have a small, yet measurable, effect on postprandial lipid metabolism. Interestingly, polymorphisms in some of the PPARa-mediated genes, such as LPL, APOC3, APOA5, and SCARB1, modify the postprandial TG response (35)(36)(37)(38)(39). In this study, we report that PPARa is involved in the homeostasis of lipids in the fasted state as well as during the acute postprandial response to dietary fat.…”

Section: Discussionmentioning

confidence: 62%

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Tanaka

Ordovas

Delgado-Lista

et al. 2007

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 62%

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Tanaka

Ordovas

Delgado-Lista

et al. 2007

Journal of Lipid Research

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“…We included only young normolipemic APOE E3/E3 males in order to avoid possible effects of different APOE isoforms or gender. Other results of these studies have been published elsewhere ( 10,23,25,28,31,(38)(39)(40)(41)(42)(43)(44)(45). No participants had diabetes or liver, renal, or thyroid disease, nor were they taking any medication.…”

Section: Resultsmentioning

confidence: 91%

“…Some variations in this gene (T-1131C and Ser19-Trp) have been linked to altered fasting and postprandial TG ( 28,29 ). Haplotype analysis based on fi ve polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene defi ne three common haplotypes ( APOA5 *1, APOA5 *2, and APOA5 *3) ( 30 ).…”

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confidence: 99%

Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men

Delgado-Lista

Pérez-Jiménez

Ruano

et al. 2010

Journal of Lipid Research

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Supplementary key words apolipoproteins • diet • gene-nutrient interaction • nutrigenomics • postprandialPronounced postprandial hypertriglyceridemia is proatherogenic ( 1 ). The extent of this phenomenon depends on several factors, both intrinsic and extrinsic. Diet is the main external determinant of postprandial lipemia magnitude. It has been stated that carbohydrate intake increases the plasma concentration of postprandial lipid particles [triacylglycerols (TGs) and VLDL] when replacing fat in the diet ( 2, 3 ). Dietary fat type also infl uences postprandial lipemia. Saturated fats induce a prolonged lipemia compared with other types of fat ( 4 ). Diets rich in monounsaturated fat provoke a faster postprandial TGrich lipoprotein (TRL) clearance when compared with diets pronounced in saturated fat, thus, shortening the lipemia, which may be mediated by postprandial apolipoproteins ( 5 ) and TRL metabolism ( 6 ). Diets rich in N3 PUFA (>2.7-4 g/d) can lower the postprandial TG response ( 7 ). The effects of diet on postprandial metabolism were detailed elsewhere ( 4 ).In addition to external determinants, others that are specifi c to the individual may modulate the response to dietary interventions. A number of genes have been identifi ed as responsible for triglyceride concentration in both the fast- Abbreviations: APOA1, apolipoprotein A1; APOC3, apolipoprotein C-III; APOA4, apolipoprotein A-IV; APOA5, apolipoprotein V; AUC, area under the curve; BMI, body mass index; CETP, cholesteryl ester transfer protein; CHOL, cholesterol; EBF1, early B-cell factor 1; HWE, Hardy-Weinberg equilibrium; LD, linkage disequilibrium; SNP, single nucleotide polymorphism; SRF, serum response factor;TG, triacylglycerol; TRL, TG-rich lipoprotein.

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“…Several studies have examined the impact of various apoAV polymorphisms on postprandial lipemia. Moreno et al (17) and Jang et al (18) demonstrated that carriers of the (/1131T/C allele had significantly increased postprandial lipemia. However, other studies do not support this.…”

Section: Apoproteins and Other Cofactorsmentioning

confidence: 98%

Regulation of fatty acid transport and storage: influence of acylation-stimulating protein

Cianflone¹,

Paglialunga²

2006

Scandinavian Journal of Food and Nutrition

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Postprandial lipemia and fatty acid fluxes occur several times daily, resulting in very efficient absorption of dietary fat and redistribution to various tissues. Absorbed dietary lipids are incorporated into chylomicrons to distribute triglycerides either for storage in adipose tissue or for immediate use in muscle. Commonly, the dietary sources of fat exceed the actual needs and the tissues are faced with dealing with the excess. Under these circumstances, the removal process of dietary triglycerides and fatty acids becomes overloaded, resulting in excessive postprandial lipemia and accumulation of chylomicrons, remnant particles and non-esterified fatty acids. These particles are associated with disruptions in lipoprotein metabolism and changes in inflammatory factors, thus their association with cardiovascular disease, metabolic syndrome and diabetes is not surprising. Dietary factors, not just fat, influence postprandial fluxes. This leads to the question: do we need a standardized fat tolerance test? The recognition of the factors influencing postprandial lipemia and fatty acid uptake and clearance is constantly increasing. Numerous proteins, transporters, enzymes and hormones have been shown to affect fatty acid flux at the level of absorption, peripheral uptake and hepatic remnant clearance. This summary targets fatty acid fluxes, with a focus on acylation-stimulating protein.

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A single nucleotide polymorphism of the apolipoprotein A–V gene −1131T>C modulates postprandial lipoprotein metabolism

Cited by 30 publications

References 34 publications

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men

Regulation of fatty acid transport and storage: influence of acylation-stimulating protein

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