A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles

Arai, Atsushi; Hirota, Yu; Miyase, Naoki; Miyata, Shiori; Young, Larry J.; Osako, Yoichi; Yuri, Kazunari; Mitsui, Shinichi

doi:10.1016/j.bbr.2016.08.022

Cited by 19 publications

(12 citation statements)

References 59 publications

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“…To reflect species differences in swimming propensity, when SPS procedures were applied to adult male mice and prairie voles, the forced swim was reduced by 10 and 15 min, respectively (Arai et al, 2016;Perrine et al, 2016). To offset the potentially reduced impact of the truncated forced swim, the mouse-SPS model includes 15 min of predator scent exposure (for more detail, see the Methodological Considerations for SPS in Mice section).…”

Section: Methodological Considerations: Single Prolonged Stress: Restraint Stressmentioning

confidence: 99%

Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents

Ferland‐Beckham

Chaby

Daskalakis

et al. 2021

Front. Behav. Neurosci.

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Posttraumatic stress disorder (PTSD) is a mental health condition triggered by experiencing or witnessing a terrifying event that can lead to lifelong burden that increases mortality and adverse health outcomes. Yet, no new treatments have reached the market in two decades. Thus, screening potential interventions for PTSD is of high priority. Animal models often serve as a critical translational tool to bring new therapeutics from bench to bedside. However, the lack of concordance of some human clinical trial outcomes with preclinical animal efficacy findings has led to a questioning of the methods of how animal studies are conducted and translational validity established. Thus, we conducted a systematic review to determine methodological variability in studies that applied a prominent animal model of trauma-like stress, single prolonged stress (SPS). The SPS model has been utilized to evaluate a myriad of PTSD-relevant outcomes including extinction retention. Rodents exposed to SPS express an extinction retention deficit, a phenotype identified in humans with PTSD, in which fear memory is aberrantly retained after fear memory extinction. The current systematic review examines methodological variation across all phases of the SPS paradigm, as well as strategies for behavioral coding, data processing, statistical approach, and the depiction of data. Solutions for key challenges and sources of variation within these domains are discussed. In response to methodological variation in SPS studies, an expert panel was convened to generate methodological considerations to guide researchers in the application of SPS and the evaluation of extinction retention as a test for a PTSD-like phenotype. Many of these guidelines are applicable to all rodent paradigms developed to model trauma effects or learned fear processes relevant to PTSD, and not limited to SPS. Efforts toward optimizing preclinical model application are essential for enhancing the reproducibility and translational validity of preclinical findings, and should be conducted for all preclinical psychiatric research models.

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Section: Methodological Considerations: Single Prolonged Stress: Restraint Stressmentioning

confidence: 99%

Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents

Ferland‐Beckham

Chaby

Daskalakis

et al. 2021

Front. Behav. Neurosci.

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“…Immunohistochemistry was performed at room temperature as described previously. 26 , 27 Sections were treated with PBS containing 6% H 2 O 2 and 30% methanol for 20 minutes to inactivate endogenous peroxidase after washing with PBS for 10 minutes, three times. Next, they were washed with PBS containing 0.3% Triton X-100 (PBS-T) three times and incubated overnight with rabbit anti-cFos antibody (SC-52; Santa Cruz Biotechnology Inc., Dallas, TX, USA, 1:1,000 dilution in PBS-T containing 1% BSA).…”

Section: Methodsmentioning

confidence: 99%

Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors

Hidaka¹,

Kashio²,

Uchigaki³

et al. 2018

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BackgroundBoth environmental and genetic conditions contribute to the robust development of neuronal circuits and adulthood behaviors. Loss of motopsin gene function causes severe intellectual disability in humans and enhanced social behavior in mice. Furthermore, childhood maltreatment is a risk factor for some psychiatric disorders, and children with disabilities have a higher risk of abuse than healthy children.Materials and methodsIn this study, we investigated the effects of maternal separation (MS) on adulthood behaviors of motopsin knockout (KO) and wild-type (WT) mice.ResultsThe MS paradigm decreased the duration that WT mice stayed in the center area of an open field, but not for motopsin KO mice; however, it decreased the novel object recognition index in both genotypes. In the marble burying test, motopsin KO mice buried fewer marbles than WT mice, regardless of the rearing conditions. The MS paradigm slightly increased and reduced open arm entry in the elevated plus maze by WT and motopsin KO mice, respectively. In the three-chamber test, the rate of sniffing the animal cage was increased by the MS paradigm only for motopsin KO mice. After the three-chamber test, motopsin KO mice had fewer cFos-positive cells in the prelimbic cortex, which is involved in emotional response, than WT mice. In the infralimbic cortex, the MS paradigm decreased the number of cFos-positive cells in motopsin KO mice.ConclusionOur results suggest that motopsin deficiency and childhood adversity independently affect some behaviors, but they may interfere with each other for other behaviors. Defective neuronal circuits in the prefrontal cortex may add to this complexity.

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“…A possible role for the VP V1bR is beyond the scope of this review, but effects of stress and OT on the VP V1bR also are possible ( 81 ). Among the many other molecules of importance to the regulation of OT and VP are CRH ( 87 ), GABA ( 88 ), dopamine ( 38 ), and serotonin ( 89 , 90 ); these molecules also play roles in the modulation of stress and coping. Brain region- and cell type-specific changes are another source of variation that is relevant to understanding how OT and VP interact.…”

Section: Interactive Functions Of Ot and Vpmentioning

confidence: 99%

The Oxytocin–Vasopressin Pathway in the Context of Love and Fear

2017

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Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an integrated and adaptive system, here described as the OT–VP pathway. The more ancient peptide, VP, and the V1aRs support individual survival and play a role in defensive behaviors, including mobilization and aggression. OT and OTRs have been associated with positive social behaviors and may function as a biological metaphor for social attachment or “love.” However, complex behavioral functions, including selective sexual behaviors, social bonds, and parenting require combined activities of OT and VP. The behavioral effects of OT and VP vary depending on perceived emotional context and the history of the individual. Paradoxical or contextual actions of OT also may reflect differential interactions with the OTR and V1aR. Adding to the complexity of this pathway is the fact that OT and VP receptors are variable, across species, individuals, and brain region, and these receptors are capable of being epigenetically tuned. This variation may help to explain experience-related individual and sex differences in behaviors that are regulated by these peptides, including the capacity to form social attachments and the emotional consequences of these attachments.

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A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles

Cited by 19 publications

References 59 publications

Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents

Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents

Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors

The Oxytocin–Vasopressin Pathway in the Context of Love and Fear

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