A single theory for the evolution of sex chromosomes and the two rules of speciation

Abstract

Three major empirical patterns involving sex chromosomes have been observed in higher eukaryotes: Y (or W) chromosomes are often non-recombining and degenerate; when two species hybridize, but one sex is sterile or inviable among hybrid offspring, it is most often the heterogametic sex (XY or ZW)-the so-called Haldane's rule; and the X (or Z) plays a disproportionately large effect on reproductive isolation compared to autosomes-the so-called large X effect. Each observation has generally received its own tailored explanation involving multiple genetic and evolutionary causes (1-3). Here, we show that these empirical patterns all emerge from a single theory incorporating the evolution of cis and trans-acting regulators of gene expression. This theory offers a level of parsimony and generality rarely seen in biology.