A single vaccine for the control of capripox infection in sheep and goats

Kitching, R.; Hammond, J. M.; Taylor, W. P.

doi:10.1016/s0034-5288(18)30655-6

Cited by 99 publications

(69 citation statements)

References 10 publications

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“…It did not exhibit R 6 and the sheep-like gap, but featured a real SPPV signature for all other amino acid motifs. SPPV15 (strain KS-1) was originally isolated from a sheep and later shown by restriction enzyme digestion analysis to have an LSDV profile (Kitching et al, 1987). This is confirmed in this study, as KS-1 did not possess the SPPV-like gap and had a clear LSDV signature.…”

supporting

confidence: 81%

“…These included 22 strains isolated from sheep, 12 from goats, 13 from cattle and 2 from springbok antelopes (Antidorcas marsupialis) (Supplementary Table S1, available in JGV Online). Eight of the isolates were vaccine strains: a goat pox vaccine from Kazakhstan [GTPV1 in Supplementary Table S1 (Kitching et al, 1987)], a sheep and goat vaccine strain (SPPV14 and GTPV4, respectively) used for routine vaccination in Nigeria (sent by Dr Majiyagbe, National Veterinary Research Institute, Vom, Plateau State, Nigeria), the Onderstepoort LSD Neethling vaccine strains [LSDV1, partial sequence (Fick & Viljoen, 1994) and LSDV3 full genome sequence (Kara et al, 2003)], an LSD vaccine used in Nigeria (LSDV8), the Romanian sheep pox vaccine strain produced by Biopharma, in Morocco (SPPV11), a sheep pox vaccine from Kazakhstan [SPPV3 (Tulman et al, 2002)], the sheep pox vaccine strain Nihkhi from Kazakhstan [SPPV3 (Tulman et al, 2002)] and the Kenya sheep vaccine isolate of LSDV [KS-1, SPPV15 (Kitching et al, 1987)]. They were compared to the corresponding sequences of three SPPV, two GTPV and four LSDV isolates retrieved from GenBank in October 2008.…”

Section: Methodsmentioning

confidence: 99%

“…The host preference for goat poxviruses was recently demonstrated experimentally (Babiuk et al, 2009); however, the breed of the sheep and goat used might account for this difference. There is at least one confirmed isolation of an LSDV isolate from a sheep, the Kenyan O-240 isolate (KS-1) (Davies, 1976(Davies, , 1982Kitching et al, 1987). In southern Africa, there have never been reports of CaPV-like diseases in sheep or goats, whereas there are outbreaks of LSD in cattle every few years (Hunter & Wallace, 2001;Weiss, 1968).…”

Section: Capvmentioning

confidence: 99%

“…An in-depth epidemiological investigation to specifically identify the viruses involved in acute small ruminant pox diseases cannot be achieved by serological testing alone due to the very close antigenic relationship between CaPVs, with the existence of only one serotype (Kitching et al, , 1989. The common immunogenic properties of these viruses have been used for the preparation of live attenuated vaccines that protect all ruminants against CaPV infection (Kitching et al, 1987). Recombinant CaPVs have also been developed for multivalent vaccination purposes (Berhe et al, 2003;Perrin et al, 2007;Romero et al, 1993;Wade-Evans et al, 1996;Wallace et al, 2006).…”

mentioning

confidence: 99%

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Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discrimination

Goff

Lamien

Fakhfakh

et al. 2009

Journal of General Virology

143

142

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The genus Capripoxvirus within the family Poxviridae comprises three closely related viruses, namely goat pox, sheep pox and lumpy skin disease viruses. This nomenclature is based on the animal species from which the virus was first isolated, respectively, goat, sheep and cattle. Since capripoxviruses are serologically identical, their specific identification relies exclusively on the use of molecular tools. We describe here the suitability of the G-protein-coupled chemokine receptor (GPCR) gene for use in host-range grouping of capripoxviruses. The analysis of 58 capripoxviruses showed three tight genetic clusters consisting of goat pox, sheep pox and lumpy skin disease viruses. However, a few discrepancies exist with the classical virus-host origin nomenclature: a virus isolated from sheep is grouped in the goat poxvirus clade and vice versa. Intra-group diversity was further observed for the goat pox and lumpy skin disease virus isolates. Despite the presence of nine vaccine strains, no genetic determinants of virulence were identified on the GPCR gene. For sheep poxviruses, the addition or deletion of 21 nucleic acids (7 aa) was consistently observed in the 59 terminal part of the gene. Specific signatures for each cluster were also identified. Prediction of the capripoxvirus GPCR topology, and its comparison with other known mammalian GPCRs and viral homologues, revealed not only a classical GPCR profile in the last three-quarters of the protein but also unique features such as a longer N-terminal end with a proximal hydrophobic a-helix and a shorter serine-rich C-tail.3These authors contributed equally to this work.Two supplementary tables are available with the online version of this paper.Journal of General Virology (2009), 90, 1967-1977 DOI 10.1099 Davies, 1981Davies, , 1982Diallo & Viljoen, 2007). CaPV infections lead to similar clinical signs in sheep and goats, mainly characterized by fever, excess salivation, conjunctivitis and rhinitis with ocular and nasal discharges. These symptoms are followed by eruption of pox lesions throughout the skin. LSD is a subacute to acute cattle disease with appearance of skin nodules. During epizootics of CaPVs in domestic animals, disease in wild ungulates has never been reported (Davies, 1991), although serology and isolated cases suggests that wildlife species have a possible role in virus maintenance.CaPVs are generally considered to be host-specific, leading to outbreaks in one preferred host. This is partially true since some SPPV and GTPV isolates are capable of causing severe diseases in both sheep and goats (Davies, 1976;Kitching et al., 1989). An in-depth epidemiological investigation to specifically identify the viruses involved in acute small ruminant pox diseases cannot be achieved by serological testing alone due to the very close antigenic relationship between CaPVs, with the existence of only one serotype (Kitching et al., , 1989. The common immunogenic properties of these viruses have been used for the preparation of live attenuated vaccines that ...

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supporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Capvmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discrimination

Goff

Lamien

Fakhfakh

et al. 2009

Journal of General Virology

143

142

View full text Add to dashboard Cite

show abstract

“…Neither of the recipient animals developed antibody levels detectable using SNT. It is, however, known that the immunity against LSDV is predominantly cell-mediated, and none of the serological assays that are currently available are sufficiently sensitive to detect antibodies consistently during and after mild infections of LSD (Kitching et al, 1987).…”

Section: Discussionmentioning

confidence: 99%