A six-participant pilot single-subject study of an individualized pain management program for people with spinal cord injury

Proulx, Ketsia; Lamontagne, Marie-Ève; Quirion, René; Deaudelin, Isabelle; Mercier, Catherine; Perreault, Kadija

doi:10.1038/s41394-022-00557-z

Cited by 1 publication

(4 citation statements)

References 22 publications

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“…A range of NeuP conditions were studied, but overall, painful diabetic peripheral neuropathy was the most common (27%, n = 9), 41 , 43 , 50 , 51 , 55 , 57 , 59 , 60 , 63 closely followed by NeuP associated with SCI (24%, n = 8). 12 , 30 , 32 , 45–47 , 49 , 68 Four (12%) studies included individuals with phantom limb/breast pain. 52 , 64–66 There were 3 (9%) studies each for multiple NeuP conditions 31 , 44 , 48 and for postherpetic neuralgia.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, 1 study that used a single-subject design was accepted to have mixed results, as the significant results were found in some but not all of the participants in the study. 49 In contrast, if the studies reported significant outcomes immediately at posttreatment but not at subsequent follow-ups (ie, no maintenance), the results were still classified as “significant.” This is because it is expected that the treatment effects are likely to be at the strongest immediately after the treatment, and it is not clear whether the sudden improvement at later points could be attributed to the treatment. For RCTs and controlled pre–post studies, the results were considered “significant” or “mixed” only if the significant group differences were found in the direction expected.…”

Section: Resultsmentioning

confidence: 99%

“…Significant results are reported in 6 (40%) of the studies that reported on pain, 12 , 41 , 44 , 48 , 51 , 53 6 (38%) of the studies that assessed disability, 12 , 32 , 41 , 44 , 48 , 51 and 3 (19%) of the studies that measured distress. 41 , 44 , 48 Additionally, some significant but mixed results are reported in 2 (13%) of the studies that assessed pain, 49 , 50 3 (19%) of the studies that measured disability, 46 , 49 , 53 and 6 (38%) of the studies that examined distress. 12 , 45 , 47 , 49 , 50 , 53 …”

Section: Resultsmentioning

confidence: 99%

“… 41 , 44 , 48 Additionally, some significant but mixed results are reported in 2 (13%) of the studies that assessed pain, 49 , 50 3 (19%) of the studies that measured disability, 46 , 49 , 53 and 6 (38%) of the studies that examined distress. 12 , 45 , 47 , 49 , 50 , 53 …”

Section: Resultsmentioning

confidence: 99%

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Psychologically based interventions for adults with chronic neuropathic pain: a scoping review

Oguchi,

Nicholas,

Asghari

et al. 2024

Pain Medicine

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Objective As psychologically-based interventions have been shown to have clinical utility for adults with chronic pain generally, a similar benefit might be expected in the management of chronic neuropathic pain (NeuP). However, to date this has not been established, with existing systematic reviews on this topic being hampered by the scarcity of Randomised Controlled Trials (RCTs). This review aimed to identify the type of psychologically-based interventions studied for adults with chronic NeuP. It also aimed to assess whether there are enough RCTs to justify undertaking an updated systematic review. Methods Seven databases and two clinical trial registries were searched for NeuP and psychologically-based interventions from database inception to December 2021, and the search was updated in February 2023. The search was broadened by reviewing the reference list of included studies and contacting field experts. Predetermined study characteristics were extracted. Results Of 4682 records screened, 33 (less than 1%) articles met the eligibility criteria. Four broad intervention approaches were observed, including cognitive-behavioural approaches (n = 16), mindfulness/meditation (n = 10), trauma focused therapy (n = 4), and hypnosis (n = 3). Thirteen RCTs were identified, and of these, nine retained 20 participants in each arm at post-treatment. Conclusions Cognitive Behavioural Therapy was the most common therapeutic approach identified, whereas mindfulness/meditation was the most frequently used technique. Almost half to two-thirds of the studies reported significant improvements in either pain, disability, or distress, suggesting psychologically-based interventions are potentially beneficial for adults with chronic NeuP. An updated systematic review seems warranted.

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