A skin-conformable wireless sensor to objectively quantify symptoms of pruritus

Chun, Keum San; Kang, Youn J.; Lee, Jong Yoon; Nguyen, Morgan; Lee, Brad; Lee, Rachel; Jo, Han Heul; Allen, E. D.; Chen, Hope; Kim, Jung-Woo; Yu, Lian; Ni, Xiaoyue; Lee, Kun Hyuck; Jeong, Hyoyoung; Lee, Joo Hee; Park, Yoonseok; Chung, Ha Uk; Li, Alvin W.; Lio, Peter; Yang, Albert F.; Fishbein, Anna; Paller, Amy S.; Rogers, John A.; Xu, Shuai

doi:10.1126/sciadv.abf9405

Cited by 47 publications

(32 citation statements)

References 31 publications

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“…Scratch algorithm development performed in healthy subjects yielded high sensitivity and specificity with comparable performance among AD datasets using an IR camera gold standard, even with confounders. 38 , 39 A comparison of data outputs for scratch from actigraphy, smartwatch application, and mechano-acoustic device is shown in Supplemental Fig 1.…”

Section: Discussionmentioning

confidence: 99%

Use of technology for the objective evaluation of scratching behavior: A systematic review

Yang

Nguyen

et al. 2021

JAAD International

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Introduction: Pruritus is a common symptom across various dermatologic conditions, with a negative impact on quality of life. Devices to quantify itch objectively primarily use scratch as a proxy. This review compares and evaluates the performance of technologies aimed at objectively measuring scratch behavior.Methods: Articles identified from literature searches performed in October 2020 were reviewed and those that did not report a primary statistical performance measure (eg, sensitivity, specificity) were excluded. The articles were independently reviewed by 2 authors. Results:The literature search resulted in 6231 articles, of which 24 met eligibility criteria. Studies were categorized by technology, with actigraphy being the most studied (n = 21). Wrist actigraphy's performance is poorer in pruritic patients and inherently limited in finger-dominant scratch detection. It has moderate correlations with objective measures (Eczema and Area Severity Index/Investigator's Global Assessment: r s (r) = 0.70-0.76), but correlations with subjective measures are poor (r 2 = 0.06, r s (r) = 0.18-0.40 for itch measured using a visual analog scale). This may be due to varied subjective perception of itch or actigraphy's underestimation of scratch. Conclusion:Actigraphy's large variability in performance and limited understanding of its specificity for scratch merits larger studies looking at validation of data analysis algorithms and device performance, particularly within target patient populations.

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Section: Discussionmentioning

confidence: 99%

Use of technology for the objective evaluation of scratching behavior: A systematic review

Yang

Nguyen

et al. 2021

JAAD International

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“…New-onset rashes may be best temporally tagged with activity monitoring that identifies new or worsening instances of itching. Wearable sensor patches have been developed that can sense the act of itching and can be utilized in the setting of PASC [ 65 ]. Alternatively, cameras trained to recognize users may be able to identify new visible lesions, though such technology is currently far from being commercially or medically viable and alternative non-camera sensing is preferred as users have demonstrated concerns of poor privacy and discomfort with camera-based sensors [ 66 ].…”

Section: Quantitatively Measurable Pasc Symptomsmentioning

confidence: 99%

The Role of Unobtrusive Home-Based Continuous Sensing in the Management of Postacute Sequelae of SARS CoV-2

Corman¹,

Rajupet²,

Ye³

et al. 2022

J Med Internet Res

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Amid the COVID-19 pandemic, it has been reported that greater than 35% of patients with confirmed or suspected COVID-19 develop postacute sequelae of SARS CoV-2 (PASC). PASC is still a disease for which preliminary medical data are being collected—mostly measurements collected during hospital or clinical visits—and pathophysiological understanding is yet in its infancy. The disease is notable for its prevalence and its variable symptom presentation, and as such, management plans could be more holistically made if health care providers had access to unobtrusive home-based wearable and contactless continuous physiologic and physical sensor data. Such between-hospital or between-clinic data can quantitatively elucidate a majority of the temporal evolution of PASC symptoms. Although not universally of comparable accuracy to gold standard medical devices, home-deployed sensors offer great insights into the development and progression of PASC. Suitable sensors include those providing vital signs and activity measurements that correlate directly or by proxy to documented PASC symptoms. Such continuous, home-based data can give care providers contextualized information from which symptom exacerbation or relieving factors may be classified. Such data can also improve the collective academic understanding of PASC by providing temporally and activity-associated symptom cataloging. In this viewpoint, we make a case for the utilization of home-based continuous sensing that can serve as a foundation from which medical professionals and engineers may develop and pursue long-term mitigation strategies for PASC.

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“…The basic principles of such types of mechano-acoustic (MA) measurements of body processes can be found elsewhere [19][20][21][22] . Briefly, a wide-bandwidth inertial measurement unit (IMU) captures motions at the skin's surface, ranging from vibratory oscillations associated with vocalizations and cardiac sounds to bulk body movements related to walking and jumping.…”

Section: Introductionmentioning

confidence: 99%

Soft skin-interfaced mechano-acoustic sensors for real-time monitoring and patient feedback on respiratory and swallowing biomechanics

et al. 2022

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Swallowing is a complex neuromuscular activity regulated by the autonomic nervous system. Millions of adults suffer from dysphagia (impaired or difficulty swallowing), including patients with neurological disorders, head and neck cancer, gastrointestinal diseases, and respiratory disorders. Therapeutic treatments for dysphagia include interventions by speech-language pathologists designed to improve the physiology of the swallowing mechanism by training patients to initiate swallows with sufficient frequency and during the expiratory phase of the breathing cycle. These therapeutic treatments require bulky, expensive equipment to synchronously record swallows and respirations, confined to use in clinical settings. This paper introduces a wireless, wearable technology that enables continuous, mechanoacoustic tracking of respiratory activities and swallows through movements and vibratory processes monitored at the skin surface. Validation studies in healthy adults (n = 67) and patients with dysphagia (n = 4) establish measurement equivalency to existing clinical standard equipment. Additional studies using a differential mode of operation reveal similar performance even during routine daily activities and vigorous exercise. A graphical user interface with real-time data analytics and a separate, optional wireless module support both visual and haptic forms of feedback to facilitate the treatment of patients with dysphagia.

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A skin-conformable wireless sensor to objectively quantify symptoms of pruritus

Cited by 47 publications

References 31 publications

Use of technology for the objective evaluation of scratching behavior: A systematic review

Use of technology for the objective evaluation of scratching behavior: A systematic review

The Role of Unobtrusive Home-Based Continuous Sensing in the Management of Postacute Sequelae of SARS CoV-2

Soft skin-interfaced mechano-acoustic sensors for real-time monitoring and patient feedback on respiratory and swallowing biomechanics

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