A smart bioresponsive nanosystem with dual-modal imaging for drug visual loading and targeted delivery

Peng, Jingyi; Gong, Peiwei; Li, Shuohan; Kong, Fei; Ge, Xingxing; Wang, Bin; Guo, Lihua; Liu, Zhe; You, Jinmao

doi:10.1016/j.cej.2019.123619

Cited by 43 publications

(18 citation statements)

References 56 publications

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“…These results are consistent with other authors' results that demonstrate the biocompatibility of different nanomaterials [17,55]. The authors repot novel and smart nanosystems and proved their good specificity and stability, visual detection of drug loading, responsive biodegradation and drug release, effective cancer chemotherapy and anti-migration.…”

Section: Treatment With Go-peg With and Without Nir Slightly Impaired The Cell Cycle Of Colorectal Cell Carcinoma Cells At 24 H Of Incubasupporting

confidence: 91%

Bioactivity of PEGylated Graphene Oxide Nanoparticles Combined with Near-Infrared Laser Irradiation Studied in Colorectal Carcinoma Cells

et al. 2021

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Central focus in modern anticancer nanosystems is given to certain types of nanomaterials such as graphene oxide (GO). Its functionalization with polyethylene glycol (PEG) demonstrates high delivery efficiency and controllable release of proteins, bioimaging agents, chemotherapeutics and anticancer drugs. GO–PEG has a good biological safety profile, exhibits high NIR absorbance and capacity in photothermal treatment. To investigate the bioactivity of PEGylated GO NPs in combination with NIR irradiation on colorectal cancer cells we conducted experiments that aim to reveal the molecular mechanisms of action of this nanocarrier, combined with near-infrared light (NIR) on the high invasive Colon26 and the low invasive HT29 colon cancer cell lines. During reaching cancer cells the phototoxicity of GO–PEG is modulated by NIR laser irradiation. We observed that PEGylation of GO nanoparticles has well-pronounced biocompatibility toward colorectal carcinoma cells, besides their different malignant potential and treatment times. This biocompatibility is potentiated when GO–PEG treatment is combined with NIR irradiation, especially for cells cultured and treated for 24 h. The tested bioactivity of GO–PEG in combination with NIR irradiation induced little to no damages in DNA and did not influence the mitochondrial activity. Our findings demonstrate the potential of GO–PEG-based photoactivity as a nanosystem for colorectal cancer treatment.

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Section: Treatment With Go-peg With and Without Nir Slightly Impaired The Cell Cycle Of Colorectal Cell Carcinoma Cells At 24 H Of Incubasupporting

confidence: 91%

Bioactivity of PEGylated Graphene Oxide Nanoparticles Combined with Near-Infrared Laser Irradiation Studied in Colorectal Carcinoma Cells

et al. 2021

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“…Recently, photophysical analytical techniques, particularly fluorescence-based versions, have become widespread for their high sensitivity, low detection limits, low cost, convenience, and suitability for bioimaging. [22][23][24][25][26][27][28][29][30] The design of novel fluorescent probes including fluorophoric molecules, metal nanoclusters, and carbon dots (CDs), has also gained recognition. 31,32 The detection mechanisms of these fluorescent probes have depended mainly on interactions between the functional groups of the probes and the thiol/amino groups of Cys or the imidazole/amino groups of L-His.…”

Section: Introductionmentioning

confidence: 99%

A water-soluble copper-immobilized covalent organic framework functioning as an “OFF–ON” fluorescent sensor for amino acids

et al. 2021

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“…The quenching of DOX in the NP as a result of the FRET between DOX and NIR polymer was used to probe DOX release intracellularly [ 62 ]. Other FRET pairs have also been developed to probe responsible drug release and degradation, such as FRET pairs using carbon quantum dots (CQDs) and DOX, nano-MnO 2 and CQDs [ 49 ], aggregation-induced emission (AIE) dyes and DOX [ 22 ].…”

Section: Fret For Monitoring Drug Releasementioning

confidence: 99%

FRET Ratiometric Nanoprobes for Nanoparticle Monitoring

et al. 2021

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Fluorescence labelling is often used for tracking nanoparticles, providing a convenient assay for monitoring nanoparticle drug delivery. However, it is difficult to be quantitative, as many factors affect the fluorescence intensity. Förster resonance energy transfer (FRET), taking advantage of the energy transfer from a donor fluorophore to an acceptor fluorophore, provides a distance ruler to probe NP drug delivery. This article provides a review of different FRET approaches for the ratiometric monitoring of the self-assembly and formation of nanoparticles, their in vivo fate, integrity and drug release. We anticipate that the fundamental understanding gained from these ratiometric studies will offer new insights into the design of new nanoparticles with improved and better-controlled properties.

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A smart bioresponsive nanosystem with dual-modal imaging for drug visual loading and targeted delivery

Cited by 43 publications

References 56 publications

Bioactivity of PEGylated Graphene Oxide Nanoparticles Combined with Near-Infrared Laser Irradiation Studied in Colorectal Carcinoma Cells

Bioactivity of PEGylated Graphene Oxide Nanoparticles Combined with Near-Infrared Laser Irradiation Studied in Colorectal Carcinoma Cells

A water-soluble copper-immobilized covalent organic framework functioning as an “OFF–ON” fluorescent sensor for amino acids

FRET Ratiometric Nanoprobes for Nanoparticle Monitoring

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