A Snapshot of Ionic-Liquid-Tagged Proline-Based Organocatalysts

Abstract

This highlight focuses on the developments in ionic-liquid (IL)-tagged proline-based organocatalysts. An overview of catalyst structure and application to asymmetric transformations is provided, and a representative synthesis of an IL-tagged organocatalyst is also discussed.

Update 1 of: Ionic Liquids in Heterocyclic Synthesis

“…Recently, several reports of this class of catalyst , have been published with major contributions from the groups of Lombardo and Liebscher . Most recently, Brozinski and colleagues also synthesized a catalyst from this new class.…”

An Ionic Liquid Containing L‐Proline Moiety as Highly Efficient and Recyclable Chiral Organocatalyst for Michael Addition

“…Recently, supported chiral organocatalysts including proline and proline derivatives on various materials to improve its recyclability have been the subject of some reviews . Usually, these materials, such as polymer, silica, ionic liquid, magnetite nanoparticles, dendrimer, and cyclodextrin, were considered as supports for the immobilization of proline and proline derivatives. In these supports, ionic liquids have attracted considerable attention based on its high thermal stability, negligible vapor pressure, high loading capacity, and easy recyclability .…”