A solid supported palladium(0) nano/microparticle catalyzed ultrasound induced continuous flow technique for large scale Suzuki reactions

Shil, Arun K.; Guha, Nitul Ranjan; Sharma, Dharminder; Das, Pralay

doi:10.1039/c3ra41364k

Cited by 32 publications

(20 citation statements)

References 31 publications

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“…Aryl iodides having different substituents were explored without significant change in their reactivity. The activation of the aryl chloride was more difficult than expected, but gave good yields using this methodology (Scheme 15) [101]. Reactions of various aryl iodides with phenylboronic acids gave excellent yields.…”

Section: Scheme 12mentioning

confidence: 99%

“…The activation of the aryl chloride was more difficult than expected, but gave good yields using this methodology (Scheme 15) [101]. The catalytic stability in MeOH-H2O under flow conditions was studied by Das and a mechanism was proposed (Scheme 16) [101]. No significant loss of activity was observed after recycling five times.…”

Section: Scheme 12mentioning

confidence: 99%

“…Aryl iodides having different substituents were explored without significant change in their reactivity. The activation of the aryl chloride was more difficult than expected, but gave good yields using this methodology (Scheme 15) [101]. The catalytic stability in MeOH-H2O under flow conditions was studied by Das and a mechanism was proposed (Scheme 16) [101].…”

Section: Scheme 12mentioning

confidence: 99%

“…In their hands, the SEM analysis of SS-Pd showed the presence of Pd(0) nanomicroparticulates on the solid support which implies its reusability and minimum leaching of Pd from the solid surface. The catalytic stability in MeOH-H 2 O under flow conditions was studied by Das and a mechanism was proposed (Scheme 16) [101]. No significant loss of activity was observed after recycling five times.…”

Section: Scheme 12mentioning

confidence: 99%

“…Ultrasonication of the mixture (20 kHz) was realized and the reaction product was poured through b into the reservoir. Two exits (d and g) were present to A large-scale Suzuki-Miyaura cross-coupling reaction using solid supported palladium Pd 0 nano/microparticles and ultrasound irradiation was reported in continuous flow by Das [101]. The continuous flow technique used by the authors required a syringe, a reservoir, a pump and a reaction vessel.…”

Section: Scheme 12mentioning

confidence: 99%

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Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

et al. 2017

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Carbon-carbon cross-coupling reactions are among the most important processes in organic chemistry and Suzuki-Miyaura reactions are the most widely used protocols. For a decade, green chemistry and particularly catalysis and continuous flow, have shown immense potential in achieving the goals of "greener synthesis". To date, it seems difficult to conceive the chemistry of the 21st century without the industrialization of continuous flow process in the area of pharmaceuticals, drugs, agrochemicals, polymers, etc. A large variety of palladium Suzuki-Miyaura cross-coupling reactions have been developed using a continuous flow sequence for preparing the desired biaryl derivatives. Our objective is to focus this review on the continuous flow Suzuki-Miyaura cross-coupling using homogeneous and heterogeneous catalysts.

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Section: Scheme 12mentioning

confidence: 99%

Section: Scheme 12mentioning

confidence: 99%

“…Aryl iodides having different substituents were explored without significant change in their reactivity. The activation of the aryl chloride was more difficult than expected, but gave good yields using this methodology (Scheme 15) [101]. The catalytic stability in MeOH-H2O under flow conditions was studied by Das and a mechanism was proposed (Scheme 16) [101].…”

Section: Scheme 12mentioning

confidence: 99%

Section: Scheme 12mentioning

confidence: 99%

Section: Scheme 12mentioning

confidence: 99%

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Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

et al. 2017

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Palladium‐Catalyzed Cross‐Coupling in Continuous Flow at Room and Mild Temperature

Len

2018

Sustainable Catalysis

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Supported Catalysis in Continuous‐Flow Microreactors

2015

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This review surveys the recent developments to perform heterogeneous catalysis in continuous‐flow microreactors. Three different types, namely, (i) packed‐bed, (ii) monolithic, and (iii) wall‐coated approaches are discussed to implement various kinds of catalysts in a microreactor. In addition, the applications of these supported catalysts to perform a variety of organic reactions are described. Furthermore, advantages of catalytic microreactors over classical batch reactors on one or more aspects of the reaction, such as rate, conversion, selectivity, and enantioselectivity are presented.magnified image

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A solid supported palladium(0) nano/microparticle catalyzed ultrasound induced continuous flow technique for large scale Suzuki reactions

Cited by 32 publications

References 31 publications

Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

Palladium‐Catalyzed Cross‐Coupling in Continuous Flow at Room and Mild Temperature

Supported Catalysis in Continuous‐Flow Microreactors

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