A spatiotemporal molecular switch governs plant asymmetric cell division

Guo, Xiaoyu; Park, Chan Ho; Wang, Wenfei; Nickels, Bryce E.; Dong, Juan

doi:10.1038/s41477-021-00906-0

Cited by 34 publications

(11 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Arabidopsis , AtPOLAR interacts and sequesters the GSK3-like kinase BIN2; this results in disinhibition of the stomatal lineage initiating and ACD regulating transcription factor SPEECHLESS (SPCH) before mitosis ( Houbaert et al, 2018 ; MacAlister et al, 2007 ). Right at the onset of mitosis, a BSL family phosphatase is recruited to the polarity crescent in meristemoids, which releases BIN2 ( Guo et al, 2021a ). This enables BIN2 to enter the nucleus of the larger daughter cell after the ACD, where it can downregulate SPCH and inhibit ACD potential ( Guo et al, 2021a ; Houbaert et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Right at the onset of mitosis, a BSL family phosphatase is recruited to the polarity crescent in meristemoids, which releases BIN2 ( Guo et al, 2021a ). This enables BIN2 to enter the nucleus of the larger daughter cell after the ACD, where it can downregulate SPCH and inhibit ACD potential ( Guo et al, 2021a ; Houbaert et al, 2018 ). Accordingly, mutants affecting several POLAR family members in Arabidopsis show reduced cell division capacity in meristemoids.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

Zhang

Spiegelhalder

Abrash

et al. 2022

eLife

View full text Add to dashboard Cite

Grass stomata recruit lateral subsidiary cells (SCs), which are key to the unique stomatal morphology and the efficient plant-atmosphere gas exchange in grasses. Subsidiary mother cells (SMCs) strongly polarise before an asymmetric division forms a SC. Yet apart from a proximal polarity module that includes PANGLOSS1 (PAN1) and guides nuclear migration, little is known regarding the developmental processes that form SCs. Here, we used comparative transcriptomics of developing wild-type and SC-less bdmute leaves in the genetic model grass Brachypodium distachyon to identify novel factors involved in SC formation. This approach revealed BdPOLAR, which forms a novel, distal polarity domain in SMCs that is opposite to the proximal PAN1 domain. Both polarity domains are required for the formative SC division yet exhibit various roles in guiding pre-mitotic nuclear migration and SMC division plane orientation, respectively. Nonetheless, the domains are linked as the proximal domain controls polarisation of the distal domain. In summary, we identified two opposing polarity domains that coordinate the SC division, a process crucial for grass stomatal physiology.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

Zhang

Spiegelhalder

Abrash

et al. 2022

eLife

View full text Add to dashboard Cite

show abstract

“…We propose that phosphocoding, namely distinct signal transduction through specific phosphorylation sites, contributes to the diversification of signaling specificity of the large numbers of receptor kinases in plants. In light of the recent finding of spatial recruitment of BSLs in asymmetric cell division 31 , we propose that phosphocoding and spatial recruitment together provide the signaling specificity that allows the BSU1 family of phosphatases to act in many receptor kinase pathways controlling diverse processes of growth, development, and immunity.…”

Section: Discussionmentioning

confidence: 99%

Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases

Park

Youn

et al. 2022

Nat. Plants

Self Cite

View full text Add to dashboard Cite

Hundreds of leucine-rich repeat receptor kinases (LRR-RKs) have evolved to control diverse processes of growth, development, and immunity in plants; the mechanisms that link LRR-RKs to distinct cellular responses are not understood. Here we show that two LRR-RKs, the brassinosteroid hormone receptor BRI1 (BRASSINOSTEROID INSENSITIVE 1) and the flagellin receptor FLS2 (FLAGELLIN SENSING 2), regulate downstream glycogen synthase kinase 3 (GSK3) and mitogen-activated protein (MAP) kinases, respectively, through phosphocoding of the BRI1-SUPPRESSOR1 (BSU1) phosphatase. BSU1 was previously identified as a component that inactivates GSK3s in the BRI1 pathway. We found surprisingly that loss of the BSU1 family phosphatases activates effector-triggered immunity (ETI) and impairs flagellin-triggered MAP kinase activation and immunity. The flagellinactivated BOTRYTIS-INDUCED KINASE 1 (BIK1) phosphorylates BSU1 at serine-251. Mutation of serine-251 reduces the ability of BSU1 to mediate flagellin-induced MAP kinase activation and immunity, but not its abilities to suppress ETI and interact with GSK3, which is enhanced through the phosphorylation of BSU1 at serine-764 upon brassinosteroid signaling. These results demonstrate that BSU1 plays an essential role in immunity and transduces brassinosteroid-BRI1 and flagellin-FLS2 signals using different phosphorylation sites. Our study illustrates that phosphocoding in shared downstream components provides signaling specificities for diverse plant receptor kinases.

show abstract

“…In this subcellular shuttle of the GSK proteins the BSL1 protein is involved, which is known to enhance the BR signaling (Mora-Garcia et al, 2004;Kim et al, 2009Kim et al, , 2018. BSL1 suppresses the interaction between BIN2 and BASL near the plasma membrane (Guo et al, 2021;.…”

Section: Various Mechanisms Of the Glycogen Synthase Kinase Stability...mentioning

confidence: 99%

“…On the other hand, BIN2 phosphorylates the SPCH transcription factor in the nucleus and promotes its degradation to enhance cell differentiation and repress stomata development in hypocotyls (Gudesblat et al, 2012; Figure 5). In order to effectively coordinate these two molecular mechanisms, subcellular localization of BIN2 needs to be precisely regulated by dynamic interactions of BIN2 with the two above-mentioned scaffold proteins POLAR and BASL in the cell cortex (Houbaert et al, 2018;Guo et al, 2021;. Interestingly, it is also known that BIN2 phosphorylates the POLAR protein to reduce its stability and the BASL protein to regulate its mobility and localization (Zhang Y. et al, 2016;Houbaert et al, 2018).…”

Section: Effects Of Glycogen Synthase Kinases On Activity Of Substrat...mentioning

confidence: 99%

Glycogen synthase kinases in model and crop plants – From negative regulators of brassinosteroid signaling to multifaceted hubs of various signaling pathways and modulators of plant reproduction and yield

Zolkiewicz

Gruszka

2022

Front. Plant Sci.

View full text Add to dashboard Cite

Glycogen synthase kinases, also known as SHAGGY-like Kinases (GSKs/SKs), are highly conserved serine/threonine protein kinases present both in animals and plants. Plant genomes contain multiple homologs of the GSK3 genes which participate in various biological processes. Plant GSKs/SKs, and their best known representative in Arabidopsis thaliana – Brassinosteroid Insentisive2 (BIN2/SK21) in particular, were first identified as components of the brassinosteroid (BR) signaling pathway. As phytohormones, BRs regulate a wide range of physiological processes in plants – from germination, cell division, elongation and differentiation to leaf senescence, and response to environmental stresses. The GSKs/SKs proteins belong to a group of several highly conserved components of the BR signaling which evolved early during evolution of this molecular relay. However, recent reports indicated that the GSKs/SKs proteins are also implicated in signaling pathways of other phytohormones and stress-response processes. As a consequence, the GSKs/SKs proteins became hubs of various signaling pathways and modulators of plant development and reproduction. Thus, it is very important to understand molecular mechanisms regulating activity of the GSKs/SKs proteins, but also to get insights into role of the GSKs/SKs proteins in modulation of stability and activity of various substrate proteins which participate in the numerous signaling pathways. Although elucidation of these aspects is still in progress, this review presents a comprehensive and detailed description of these processes and their implications for regulation of development, stress response, and reproduction of model and crop species. The GSKs/SKs proteins and their activity are modulated through phosphorylation and de-phosphorylation reactions which are regulated by various proteins. Importantly, both phosphorylations and de-phosphorylations may have positive and negative effects on the activity of the GSKs/SKs proteins. Additionally, the activity of the GSKs/SKs proteins is positively regulated by reactive oxygen species, whereas it is negatively regulated through ubiquitylation, deacetylation, and nitric oxide-mediated nitrosylation. On the other hand, the GSKs/SKs proteins interact with proteins representing various signaling pathways, and on the basis of the complicated network of interactions the GSKs/SKs proteins differentially regulate various physiological, developmental, stress response, and yield-related processes.

show abstract

A spatiotemporal molecular switch governs plant asymmetric cell division

Cited by 34 publications

References 60 publications

Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases

Glycogen synthase kinases in model and crop plants – From negative regulators of brassinosteroid signaling to multifaceted hubs of various signaling pathways and modulators of plant reproduction and yield

Contact Info

Product

Resources

About