A special issue about hepatotoxicity and hepatocyte in vitro systems

Highlight report: overview of hepatoprotective compounds

“…Moreover, liver in vitro systems (Chen et al 2014;Vinken et al 2014;Godoy et al 2013;2015;Ghallab 2014;Reif 2014;Godoy 2011;Ilkavets 2013;Messner et al 2013) have been intensively applied and systems biology approaches (Schliess et al 2014;Drasdo et al 2014a, b;Hoehme et al 2010) have been introduced to gain a deeper understanding of the mechanisms of hepatotoxicity. Considering this background, the present review of Domitrović and Potočnjak is a must read for anyone interested in how protective compounds can interfere with hepatotoxic mechanisms.…”

Therapy of hyperammonemia

“…Currently, hepatotoxicity represents an intensively studied topic (Campos et al, 2014[ 3 ]; Vitins et al, 2014[ 28 ]; Liu et al, 2014[ 18 ]; Messner et al, 2013[ 19 ]; Shimada et al, 2012[ 24 ]; Sumi et al, 2011[ 25 ]; Abdel-Bakhy et al, 2011[ 1 ]) and in vitro systems are frequently used in these studies (Grinberg et al, 2014[ 13 ]; Valente et al, 2015[ 26 ]; Ghallab et al, 2014[ 10 ][ 9 ]; Reif, 2014[ 22 ]; Ilkavets, 2013[ 16 ]). The study of Ghallab et al shows that some adaptive mechanisms in response to toxicity may depend on complex features of tissue architecture and may be difficult to detect in vivo .…”