A special issue on glucose transporters in health and disease

Koepsell, Hermann; Vallon, Volker

doi:10.1007/s00424-020-02442-w

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…Los transportadores dependientes de sodio se basan en el transporte activo de sodio a través de la membrana celular, que luego se difunde a favor de su gradiente de concentración junto con una molécula de glucosa (transporte activo secundario). Los transportadores independientes de sodio no dependen del sodio y transportan glucosa mediante difusión facilitada (Koepsell & Vallon, 2020).…”

Section: Absorción De La Glucosaunclassified

Nutrición animal: Texto de formación universitaria

Huanca¹

2023

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El texto que se pone a consideración del lector, en su edición digital, revisada y corregida, ha sido preparado con fines académicos, para la formación de médicos veterinarios y/o zootecnistas, en el contexto del Altiplano de Puno-Perú; sin embargo, puede servir como referencia para todo lector interesado en la nutrición animal. Incluye seis unidades temáticas: fisiología digestiva de los animales, como uno de los procesos nutricionales clave, seguida de energía (carbohidratos), lípidos, proteínas, minerales y vitaminas, y una unidad temática adicional sobre la evaluación de la composición química y calorimetría de los alimentos.

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Section: Absorción De La Glucosaunclassified

Nutrición animal: Texto de formación universitaria

Huanca¹

2023

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“…Together with SGLT1, SGLT2 resorbs glucose from blood-forming urine. It has been noted that of all tubular glucose reabsorption, SGLT1 accounts for about 10% (Koepsell & Vallon, 2020). In rats, SGLT1 has been identified on the apical side of the epithelial cells of the renal proximal tubules.…”

Section: Immunolocalisation Of Sglt2mentioning

confidence: 99%

Comparative Study of Sodium-Dependent Glucose Co-Transporters in Kidneys of Ostrich Chickens

Hussar¹,

Allmang²,

Popovska-Percinic³

et al. 2022

Scientific Horizons

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In the changing internal and external conditions, maintenance of a constant internal environment – homeostasis – plays a significant role in the proper functioning of the organism. Kidneys play a key role in the homeostasis of glucose, in which the sodium-dependent glucose co-transporters contribute to renal glucose reabsorption. Although the localisation of Na+-glucose co-transporters has been extensively covered in animals’ kidneys, the localisation of the transporters in birds’ kidneys is still understudied. The purpose of this study was to immunolocalise the sodium-dependent co-transporters SGLT1 and SGLT2 in kidneys of ostrich chickens of different ages. In the study, kidney material derived from fifteen ostriches was divided equally into three age groups – 1-, 7-, and 14-days-old ostrich chickens. The polyclonal antibodies Rabbit antiSGLT1 and Rabbit anti-SGLT2 (Abcam, UK) served as primary antibodies and were used together with the IHC kit (Abcam, UK). With the AxioCam HRc camera (Germany) connected to the microscope Zeiss Axioplan-2 Imaging (Germany), the photos were taken and saved to the computer. As the result of the study on ostrich chickens of different ages, SGLT1 was noted to be localised in the renal straight proximal tubules and SGLT2 in the proximal convoluted tubules of nephron. The immunohistochemical locations of sodium-dependent glucose co-transporters revealed to be similar in ostriches’ kidneys of all age groups. The staining for SGLT2 was noted to be more intensive compared to the staining for SGLT1. As avian kidneys have unique morphological and functional features compared to animals, it is recommended that further studies would be performed on the renal tissue of different avian species

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“…Likewise, hampered mitochondrial function would lead to the production of oxidants that impair glucose utilization 11 . Interestingly, also high concentrations of D-fructose causes central neuronal IR and promotes memory impairment in animal models through a mechanism that depends on GLUT5 12 .…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional investigation of insulin resistance in youths with autism spectrum disorder. Any role for reduced brain glucose metabolism?

et al. 2021

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The autism spectrum disorder (ASD) is an etiologically heterogeneous disorder. Dysfunctions of the intermediate metabolism have been described in some patients. We speculate these metabolic abnormalities are associated with brain insulin resistance (IR), i.e., the reduced glucose metabolism at the level of the nervous central system. The Homeostasis model assessment of insulin resistance (HOMA-IR) is very often used in population studies as estimate of peripheral IR and it has been recently recognized as proxy of brain IR. We investigated HOMA-IR in 60 ASD patients aged 4–18 years and 240 healthy controls, also aged 4–18 years, but unmatched for age, sex, body weight, or body mass index (BMI). At multivariable linear regression model, the HOMA-IR was 0.31 unit higher in ASD individuals than in controls, after having adjusted for sex, age, BMI z-score category, and lipids that are factors known to influence HOMA-IR. Findings of this preliminary study suggest it is worth investigating brain glucose metabolism in larger population of patients with ASD by using gold standard technique. The recognition of a reduced glucose metabolism in some areas of the brain as marker of autism might have tremendous impact on our understanding of the pathogenic mechanisms of the disease and in terms of public health.

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A special issue on glucose transporters in health and disease

Cited by 9 publications

References 13 publications

Nutrición animal: Texto de formación universitaria

Nutrición animal: Texto de formación universitaria

Comparative Study of Sodium-Dependent Glucose Co-Transporters in Kidneys of Ostrich Chickens

Cross-sectional investigation of insulin resistance in youths with autism spectrum disorder. Any role for reduced brain glucose metabolism?

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