A special polysaccharide hydrogel coated on<i>Brasenia schreberi</i>: preventive effects against ulcerative colitis<i>via</i>modulation of gut microbiota

Wan, Jiang; Yu, Xin; Liu, Jiao; Li, Jing; Ai, Tingyang; Yin, Cong; Liu, Hong; Qin, Rui

doi:10.1039/d2fo03207d

Cited by 7 publications

(5 citation statements)

References 68 publications

(120 reference statements)

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“…The basic information of BSM had been previously determined by our lab [ 10 ]. The moisture content was 98.72 ± 0.02%.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro antioxidation assessment showed that the polysaccharide exhibited strong free radical scavenging activities for 2,2-diphenyl-1-picrylhydrazyl (DPPH and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate)(ABTS+) radicals [ 9 ]. In our previous work, the mucilage alleviated ulcerative colitis in mice [ 10 ]. Ulcerative colitis is a chronic colorectal inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

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The Non-Denatured Processing of Brasenia schreberi Mucilage—Characteristics of Hydrodynamic Properties and the Effect on In Vivo Functions

Ai,

Wan,

et al. 2024

Foods

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Food non-denatured processes, such as freeze-drying and grinding, are commonly applied to raw materials with good bioactive functions. Although the functional components are maintained, whether structural and physical changes impact the in vivo function is often ignored in practical situations. Brasenia schreberi mucilage (BSM) has a significant alleviation effect on DSS-induced colitis. This work focused on the influence of non-denatured manufacture on the colonic benefits of BSM-based products. First, three forms of products including fresh mucilage (FM), freeze-dried products (FS), and freeze-dried powder (FP) were prepared. Then, their in vitro physiochemical properties were compared, analyzing their influence on the gut inflammation degree, microbial composition, and SCFA production in mice. The results suggested that the water retention rate of FS and FP was decreased to 34.59 ± 3.85%, and 9.93 ± 1.76%. The viscosity of FM, FS, and FP was 20.14 Pa∙s, 4.92 Pa∙s, and 0.41 Pa∙s, respectively. The freeze-drying and grinding process also damaged the lamellar microstructure of BSM. Then, animal tests showed that colitis mice intervened with FM, FS, and FP had disease activity scores of 2.03, 3.95, and 4.62. Meanwhile, FM notably changed the gut microbial composition and significantly increased propionate and butyrate levels. It seemed that the distinct colitis alleviation efficacy of BSM-based products is attributed to different hydrodynamic properties in the gut. FM had relatively higher viscosity and correspondingly high nutritional density in the gut lumen, which stimulates Firmicutes growth and promotes butyrate production, and thereby exhibited the best efficiency on protecting from colitis.

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“…The basic information of BSM had been previously determined by our lab [ 10 ]. The moisture content was 98.72 ± 0.02%.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Non-Denatured Processing of Brasenia schreberi Mucilage—Characteristics of Hydrodynamic Properties and the Effect on In Vivo Functions

Ai,

Wan,

et al. 2024

Foods

Self Cite

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“…More importantly, Lactobacillus is one of the probiotics that maintains intestinal health, as it can regulate intestinal homeostasis, host immunity, and activation of the aryl hydrocarbon receptor (AhR) pathway against intestinal mucosal barrier damage in UC [34,35]. Mucispirillum and Odoribacter are protective species to improve UC symptoms [36,37]. Mucispirillum can trigger T-cell-dependent immunoglobulin A and immunoglobulin G, and their subsequent immune responses [36,38].…”

Section: Discussionmentioning

confidence: 99%

“…Mucispirillum can trigger T-cell-dependent immunoglobulin A and immunoglobulin G, and their subsequent immune responses [36,38]. Odoribacter have an ability to protect cells from UC [37,39]. Moreover, short-chain fatty acids (SCFAs) are a well-known bacterial metabolite with anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, short-chain fatty acids (SCFAs) are a well-known bacterial metabolite with anti-inflammatory effects. Lactobacillus and Odoribacter can produce SCFAs to exert their probiotic effects on the intestinal mucosal barrier [15,37,40]. Furthermore, the integrity of the intestinal mucosal barrier depends on its interactions with gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Cordyceps militaris Powder Prophylactic Supplementation on Intestinal Mucosal Barrier Impairment and Microbiota-Metabolites Axis in DSS-Injured Mice

Wu,

Chen

2023

Nutrients

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Ulcerative colitis (UC) is a chronic and recurrent inflammatory disease with an unknown pathogenesis and increasing incidence. The objective of this study is to investigate the impact of prophylactic treatment with Cordyceps militaris on UC. The findings demonstrate that prophylactic supplementation of C. militaris powder effectively mitigates disease symptoms in DSS-injured mice, while also reducing the secretion of pro-inflammatory cytokines. Furthermore, C. militaris powder enhances the integrity of the intestinal mucosal barrier by up-regulating MUC2 protein expression and improving tight junction proteins (ZO-1, occludin, and claudin 1) in DSS-injured mice. Multiomics integration analyses revealed that C. militaris powder not only reshaped gut microbiota composition, with an increase in Lactobacillus, Odoribacter, and Mucispirillum, but also exerted regulatory effects on various metabolic pathways including amino acid, glyoxylates, dicarboxylates, glycerophospholipids, and arachidonic acid. Subsequent analysis further elucidated the intricate interplay of gut microbiota, the intestinal mucosal barrier, and metabolites, suggesting that the microbiota–metabolite axis may involve the effect of C. militaris on intestinal mucosal barrier repair in UC. Moreover, in vitro experiments demonstrated that peptides and polysaccharides, derived from C. militaris, exerted an ability to change the gut microbiota structure of UC patients’ feces, particularly by promoting the growth of Lactobacillus. These findings suggest that regulatory properties of C. militaris on gut microbiota may underlie the potential mechanism responsible for the protective effect of C. militaris in UC. Consequently, our study will provide support for the utilization of C. militaris as a whole food-based ingredient against the occurrence and development of UC.

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Prebiotics enhance the immunomodulatory effect of Limosilactobacillus fermentum DALI02 by regulating intestinal homeostasis

Zhang,

Liu,

Liu

et al. 2024

Food Science & Nutrition

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The colonization ability of Limosilactobacillus fermentum DALI02 and the promoting effect of fermented prebiotics have been studied. This study aims to evaluate the systemic immunomodulatory effects of DALI02 and DALI02 + Prebiotics on cyclophosphamide‐induced immunosuppressed rats. We found that DALI02 and DALI02 + Prebiotics, especially DALI02 + Prebiotics, exhibited significant restorative effects on the immunocompromised state in rats (p < .05). Specifically, both of them promoted the recovery of body weight and immune organ function, enhanced the proliferative capacity of immune cells, and effectively reduced the levels of interleukin 6 (IL‐6) and tumor necrosis factor‐α (TNF‐α). Furthermore, both of them significantly reduced the levels of lipopolysaccharide (LPS) and D‐lactic acid in the blood (p < .05). Principal coordinate analysis (PCoA), principal component analysis (PCA), and unsupervised cluster analysis revealed that DALI02 and DALI02 + Prebiotics group were more similar to the blank group at the genus level of the gut microbiota. At the level of short‐chain fatty acids (SCFAs), DALI02 + Prebiotics and blank group belonged to Cluster 3. These results suggested that the intervention with DALI02 and DALI02 + Prebiotics effectively modulated the structure of the gut microbiota, and DALI02 + Prebiotics restored the dysregulation of SCFAs. In summary, DALI02 and DALI02 + Prebiotics possess immunomodulatory functions, with the latter showing superior effects.

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A special polysaccharide hydrogel coated onBrasenia schreberi: preventive effects against ulcerative colitisviamodulation of gut microbiota

Abstract: Ulcerative colitis (UC) is an increasing threat to human health but it can be prevented by special daily diet intervention. Young stem and leaves of Brasenia schreberi (BS) are coated...

Cited by 7 publications

References 68 publications

The Non-Denatured Processing of Brasenia schreberi Mucilage—Characteristics of Hydrodynamic Properties and the Effect on In Vivo Functions

The Non-Denatured Processing of Brasenia schreberi Mucilage—Characteristics of Hydrodynamic Properties and the Effect on In Vivo Functions

Effect of Cordyceps militaris Powder Prophylactic Supplementation on Intestinal Mucosal Barrier Impairment and Microbiota-Metabolites Axis in DSS-Injured Mice

Prebiotics enhance the immunomodulatory effect of Limosilactobacillus fermentum DALI02 by regulating intestinal homeostasis

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