A specific, highly enriching and “green” method for hollow fiber liquid phase microextraction of ionizable pharmaceuticals from fish tissue

Boström, Marja L.; Huang, Chuixiu; Engström, Henrik A.; Larsson, Niklas; Berglund, Olof; Jönsson, Jan Åke

doi:10.1039/c4ay00470a

Cited by 17 publications

(22 citation statements)

References 38 publications

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“…Chemical extractions were conducted on separate individuals for P. pungitius and pooled samples for the other organisms using hollow-fiber liquid-phase microextraction [28]. This type A. aquaticus, 5300 AE 2100; N. glauca, 1900 AE 700, and P. pungitius, 3300 AE 1200.…”

Section: Chemical Analysismentioning

confidence: 99%

Bioaccumulation and trophodynamics of the antidepressants sertraline and fluoxetine in laboratory‐constructed, 3‐level aquatic food chains

Boström¹,

Ugge²,

Jönsson

et al. 2016

Enviro Toxic and Chemistry

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Although reports of pharmaceutical bioconcentration in aquatic organisms are increasing, less is known about trophic transfer in aquatic food webs. The bioaccumulation and trophodynamics of sertraline and fluoxetine, 2 selective serotonin reuptake inhibitors (SSRIs) frequently detected in aquatic environments, were tested by exposing constructed aquatic food chains to SSRIs under controlled laboratory conditions. Both of these ionizable, weak base pharmaceuticals showed lower bioaccumulation factors (BAFs) with increasing trophic level (i.e., no biomagnifications) in 2 3-level food chains (Acer platanoides, fed to Asellus aquaticus, in turn fed to Notonecta glauca or Pungitius pungitius). Mean sertraline BAFs in A. platanoides, A. aquaticus, N. glauca, and P. pungitus were 2200 L/kg, 360 L/kg, 26 L/kg, and 49 L/kg, respectively, and mean fluoxetine BAFs 1300 L/kg, 110 L/kg, 11 L/kg, and 41 L/kg, respectively. The weak influence of diet was further demonstrated by measured BAFs being equal to or lower than measured bioconcentration factors (BCFs). Organism lipid content was not positively correlated with BAFs, suggesting that other processes are driving interspecific differences in SSRI bioaccumulation. The empirically derived parameter values were introduced into a proposed bioaccumulation model, and a poor correlation was found between modeled and empirical BAFs (predicted r = -0.63). In conclusion, the apparent lack of biomagnification of these ionizable pharmaceuticals suggests that environmental concern should not necessarily focus only on higher trophic levels, but also on species showing high BCFs at any trophic level. Environ Toxicol Chem 2017;36:1029-1037. © 2016 SETAC.

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Section: Chemical Analysismentioning

confidence: 99%

Bioaccumulation and trophodynamics of the antidepressants sertraline and fluoxetine in laboratory‐constructed, 3‐level aquatic food chains

Boström¹,

Ugge²,

Jönsson

et al. 2016

Enviro Toxic and Chemistry

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“…18,25,32 The operational parameters used for EME in the current work were based on previous experience. 25 LPME was used to extract acidic analytes from low pH sample to high pH acceptor solution.…”

Section: Resultsmentioning

confidence: 99%

Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs

et al. 2015

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Electromembrane extraction (EME) and liquid-phase microextraction (LPME) were combined in a single step for the first time to realize simultaneous and clear group separation of basic and acidic drugs. Using 2-nitrophenyl octyl ether as the supported liquid membrane (SLM) for EME and dihexyl ether as the SLM for LPME, basic and acidic drugs were extracted and separated simultaneously from a low pH sample by EME and LPME, respectively. After 15 min of extraction, basic drugs (citalopram and sertraline) were exhaustively extracted, whereas the recoveries for acidic drugs (ketoprofen and ibuprofen) were in the range of 76%-86%. Longer extraction time provided higher recoveries for the acidic drugs, but this somewhat deteriorated the group separation. Matrices effects from the coexisting acidic drugs/basic drugs were tested, and we observed that simultaneous EME/LPME was not affected by coexisting drugs at high concentration. This approach was further investigated from human plasma. Extraction recoveries were strongly dependent on dilution of plasma with buffer and on extraction time. Finally, this simultaneous EME/LPME approach was evaluated in combination with liquid chromatography (LC)-MS. The linearity ranges for the basic and acidic drugs were 10-600 ng/mL and 1-60 μg/mL, respectively, with R(2) > 0.997 for all analytes. The repeatability at three different levels for all analytes was less than 15%. The limits of quantification (LOQ, S/N = 10) were found to be 4.0-6.3 ng/mL and 0.6-0.9 μg/mL for basic and acidic drugs, respectively. Simultaneous EME/LPME enabled efficient group separation of basic and acidic analytes under optimum experimental conditions for both EME and LPME.

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“…The basic analytes (with log P from 3.8 to 5.1) HAL, AMI, FLU, and SER (Figure ) have previously been extracted by LPME − and EME , and were selected as model analytes for the current fundamental research. Extraction conditions were partly optimized in this work to obtain comparable systems.…”

Section: Resultsmentioning

confidence: 99%

Liquid-Phase Microextraction or Electromembrane Extraction?

et al. 2019

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Isolation of substances by liquid-phase microextraction (LPME) or electromembrane extraction (EME) is becoming more and more important in analytical chemistry. However, the understanding of the mass transfer in LPME and EME is limited, especially for highly concentrated samples. In this work, the mass transfer in LPME and EME from aqueous samples (0.5–200 mg L–1) was studied in terms of recovery, equilibrium time, flux, and mass transfer capacity. In both EME and LPME, high recoveries were achieved at low analyte concentration, and the recoveries decreased at high analyte concentration. For EME, the loss in recovery was partly compensated by increasing the extraction voltage (from 50 to 200 V), while the LPME recovery at high analyte concentration was improved by increasing the extraction time (from 30 to 180 min). EME was superior in terms of equilibrium time and flux, while LPME provided much higher mass transfer capacity especially for highly concentrated samples. Moreover, the recovery was much more sensitive to high analyte concentrations in EME than in LPME, and the EME recovery decreased significantly above 50 mg L–1, indicating that LPME could be used to isolate analytes in a wider concentration range than EME. We believe that this fundamental study will be of great importance for the selection of a suitable membrane-based microextraction technique.

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A specific, highly enriching and “green” method for hollow fiber liquid phase microextraction of ionizable pharmaceuticals from fish tissue

Abstract: A specific, highly enriching and “green” method for hollow fiber liquid phase microextraction of ionizable pharmaceuticals from fish tissue is presented.

Cited by 17 publications

References 38 publications

Bioaccumulation and trophodynamics of the antidepressants sertraline and fluoxetine in laboratory‐constructed, 3‐level aquatic food chains

Bioaccumulation and trophodynamics of the antidepressants sertraline and fluoxetine in laboratory‐constructed, 3‐level aquatic food chains

Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs

Liquid-Phase Microextraction or Electromembrane Extraction?

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