A Specific microRNA Targets an Elongase of Very Long Chain Fatty Acids to Regulate Fatty Acid Composition and Mitochondrial Morphology of Skeletal Muscle Cells

Wang, Han; Hu, Mingyue; Shen, Zhonghao; Zhou, Xiao‐Long; Yang, Songbai; He, Ke; Li, Xiangchen; Yan, Feifei; Zhao, Ayong

doi:10.3390/ani12172274

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Oxidized nicotinamide adenine dinucleotide plays a beneficial role in promoting muscle development and maintaining muscle health ( Goody and Henry, 2018 ). Unsaturated fatty acids can promote muscle fiber development ( Wang et al, 2022 ). Ca 2+ is an important component of the signaling, promoting muscle formation, muscle homeostasis, and regeneration ( Tu et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…Ca 2+ is an important component of the signaling, promoting muscle formation, muscle homeostasis, and regeneration ( Tu et al, 2016 ). Moreover, the elongation of fatty acid in muscle ( Wang et al, 2022 ) and apelin signaling ( Frier et al, 2009 ) are closely related to the morphology and biogenesis of mitochondria in muscle. The smooth muscle cell ( Brozovich et al, 2016 ) and cytochrome P450 ( Hillig et al, 2003 ) are important to regulate the size of the blood vessel lumen and blood flow.…”

Section: Resultsmentioning

confidence: 99%

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Transcriptome analysis of the gene expression of M. iliotibialis lateralis affected by dietary methionine restriction

Chen

Tian

et al. 2023

Front. Physiol.

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Introduction: Methionine (Met) is an important amino acid related to the development of skeletal muscle. This study investigated the effects of dietary Met restriction on the gene expression of M. iliotibialis lateralis.Methods: A total of 84 day-old broiler chicks (Zhuanghe Dagu) with a similar initial body weight (207.62 ± 8.54 g) were used in this study. All birds were divided into two groups (CON; L-Met) based on the initial body weight. Each group consisted of six replicates with seven birds per replicate. The experimental period was 63 days (phase 1, days 1-21; phase 2, days 22-63). According to the nutritional requirements of Zhuanghe Dagu chickens, we provided a basal diet (0.39% Met levels during phase 1 and 0.35% Met levels during phase 2, as-fed basis) to the birds in the CON group, while we provided a Met-restricted diet (0.31% Met levels during phase 1 and 0.28% Met levels during phase 2, as-fed basis) to the birds in the L-Met group. The growth performance of broiler chicks and their M. iliotibialis lateralis development parameters were measured on days 21 and 63.Results and Discussion: In this study, dietary Met restriction did not affect the growth performance of broiler chicks but hindered the development of M. iliotibialis lateralis at both sampling timepoints. On the final day, three birds selected from each group (three from CON and three from L-Met) were used to obtain M. iliotibialis lateralis samples from leg muscle for further transcriptome analysis. Transcriptome analysis revealed that dietary Met restriction significantly upregulated 247 differentially expressed genes (DEGs) and downregulated 173 DEGs. Additionally, DEGs were mainly enriched in 10 pathways. Among DEGs, we observed that dietary Met restriction downregulated the expression of CSRP3, KY, FHL1, LMCD1, and MYOZ2 in M. iliotibialis lateralis. Therefore, we considered that dietary Met restriction had negative effects on the development of M. iliotibialis lateralis, and CSRP3, KY, FHL1, LMCD1, and MYOZ2 may serve as potential functional genes involved in this process.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Transcriptome analysis of the gene expression of M. iliotibialis lateralis affected by dietary methionine restriction

Chen

Tian

et al. 2023

Front. Physiol.

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Emerging insights on the role of Elovl6 in human diseases: Therapeutic challenges and opportunities

Guo,

Xue,

Wang

et al. 2025

Life Sciences

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Quantitative Prediction of Acid Value of Camellia Seed Oil Based on Hyperspectral Imaging Technology Fusing Spectral and Image Features

Gu,

Shi,

et al. 2024

Foods

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Acid value (AV) serves as an important indicator to assess the quality of oil, which can be used to judge the deterioration of edible oil. In order to realize the quantitative prediction of the AV of camellia seed oil, which was made from camellia oleifolia, hyperspectral data of 168 camellia seed oil samples were collected using a hyperspectral imaging system, which were related to their AV content measured via classical chemical titration. On the basis of hyperspectral full wavelengths, characteristic wavelengths, and fusing spectral and image features, the quantitative prediction AV models for camellia seed oil were established. The results demonstrating the 2Der-SPA-GLCM-PLSR model fusing spectral and image features stood out as the optimal choices for the AV prediction of camellia seed oil, with the correlation coefficient of calibration set (Rc2) and the correlation coefficient of prediction set (Rp2) at 0.9698 and 0.9581, respectively. Compared with those of 2Der-SPA-PLSR, the Rc2 and Rp2 were improved by 2.11% and 2.57%, respectively. Compared with those of 2Der-PLSR, the Rc2 and Rp2 were improved by 5.02% and 5.31%, respectively. Compared with the model based on original spectrum, the Rc2 and Rp2 were improved by 32.63% and 40.11%, respectively. After spectral preprocessing, characteristic wavelength selection, and fusing spectral and image features, the correlation coefficient of the optimal AV prediction model was continuously improved, while the root mean square error was continuously decreased. The research demonstrated that hyperspectral imaging technology could precisely and quantitatively predict the AV of camellia seed oil and also provide a new environmental method for detecting the AV of other edible oils, which is conducive to sustainable development.

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A Specific microRNA Targets an Elongase of Very Long Chain Fatty Acids to Regulate Fatty Acid Composition and Mitochondrial Morphology of Skeletal Muscle Cells

Cited by 4 publications

References 52 publications

Transcriptome analysis of the gene expression of M. iliotibialis lateralis affected by dietary methionine restriction

Transcriptome analysis of the gene expression of M. iliotibialis lateralis affected by dietary methionine restriction

Emerging insights on the role of Elovl6 in human diseases: Therapeutic challenges and opportunities

Quantitative Prediction of Acid Value of Camellia Seed Oil Based on Hyperspectral Imaging Technology Fusing Spectral and Image Features

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