A Specific Test of Hippocampal Deficit in Schizophrenia.

Hanlon, Faith M.; Weisend, Michael P.; Yeo, Ronald A.; Huang, Mingxiong; Lee, Ronald R.; Thoma, Robert J.; Moses, Sandra N.; Paulson, Kim; Miller, Gregory A.; Cañive, José M.

doi:10.1037/0735-7044.119.4.863

Cited by 58 publications

(87 citation statements)

References 82 publications

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“…This increased left hippocampal activation found with right hippocampal damage may allow for behavioural compensation for an impaired right hippocampus. The idea that the left hippocampus allowed for compensation for right hippocampal abnormalities is supported by the findings of Hanlon et al (2005). They found that patients with schizophrenia were more likely than healthy control participants to show left or bilateral hippocampal activation during performance of a nonverbal transverse patterning task.…”

Section: Meg Provides Direct Evidence Of Compensation In Pathologicalsupporting

confidence: 70%

“…Performance on the transverse patterning task is impaired following hippocampal damage, and is correlated with measures of hippocampal neuronal integrity (Driscoll et al, 2003). Transverse patterning deficits are also observed in conditions associated with impaired hippocampal functioning such as schizophrenia (Hanlon et al, 2005 and normal aging (Dricoll et al, 2003). Additionally, transverse patterning performance elicits hippocampal activation measured with fMRI (Astur & Constable, 2004: Melzer, Nigishi & Constable, 2008Rowland et al, 2010) and MEG (Hanlon et al, 2003;Hopf et al, in reivew;Leirer et al, 2010;Mills et al, in review, Moses et al, 2009).…”

Section: Imaging the Potential For Compensationmentioning

confidence: 99%

“…"VULG", "COSE", "RINT") to compare to the novel nonverbal abstract pictures . In healthy control participants, this verbal transverse patterning task activates the left hippocampus to a greater extent than the right , in contrast to the nonverbal transverse patterning task, which, as noted above, activates the right hippocampus to a greater degree than the left (Hanlon et al, 2003(Hanlon et al, , 2005Leirer et al, 2010;Mills et al, in review;Moses et al, 2009). This reinforces the notion that the left and right hippocampi process different information modalities, and also allows for the non-invasive evaluation of the functioning of right and left hippocampus separately.…”

Section: Meg Provides Direct Evidence Of Compensation In Pathologicalmentioning

confidence: 99%

“…The work of Hanlon et al (2003Hanlon et al ( , 2005Hanlon et al ( , 2011 demonstrates that in adults with hippocampal dysfunction, recruitment of the hippocampus bilaterally may support performance for a task that typically elicits unilateral activation. However, it is unclear whether this effect may be found in developmental populations, since children show different laterality patterns than adults.…”

Section: Meg Studies Of the Organization Of Memory Developmentmentioning

confidence: 99%

“…(e.g. Alvarado & Bachvallier, 2005;Astur & Constable, 2004;Driscoll et al, 2003;Hanlon et al, 2003Hanlon et al, , 2005Hanlon et al, , 2011Meltzer et al, 2008, Moses, Ostreicher, Rosenbaum & Ryan, 2008Moses et al, 2009;Rickard & Grafman, 1998;Rickard, Verfaellie & Grafman, 2006;Reed & Squire, 1996;Ostreicher, Ryan, Moses & Rosenbaum, 2010;Saksida et al, 2007). The transverse patterning task is structurally analogous to the childhood game "rock-paperscissors" (Rock crushes Scissors, Scissors cut Paper, Paper covers Rock), but uses novel stimuli (A, B, C) that have ambiguous meanings outside the context of their pairings (A beats B, B beats C, C beats A; or A+B-, B+C-, C+A-; Fig.…”

Section: Imaging the Potential For Compensationmentioning

confidence: 99%

See 4 more Smart Citations

Dynamic Imaging of Deep Brain Structures with MEG: Contributions to Understanding Human Memory

Moses¹,

Hanlon²,

Ryan³

2011

Magnetoencephalography

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Section: Meg Provides Direct Evidence Of Compensation In Pathologicalsupporting

confidence: 70%

Section: Imaging the Potential For Compensationmentioning

confidence: 99%

Section: Meg Provides Direct Evidence Of Compensation In Pathologicalmentioning

confidence: 99%

Section: Meg Studies Of the Organization Of Memory Developmentmentioning

confidence: 99%

Section: Imaging the Potential For Compensationmentioning

confidence: 99%

See 3 more Smart Citations

Dynamic Imaging of Deep Brain Structures with MEG: Contributions to Understanding Human Memory

Moses¹,

Hanlon²,

Ryan³

2011

Magnetoencephalography

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Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Achim

Bertrand²,

Sutton³

et al. 2007

Arch Gen Psychiatry

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Context: Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others.Objective: To examine the neural correlates of 3 specific memory processes in FEP by means of functional magnetic resonance imaging (fMRI).Design: Case-control study. Main Outcome Measures:Behavioral performance and regional brain activity measured during memory encoding by fMRI. Our fMRI design included 3 within-subject contrasts (associative vs item-oriented encoding, encoding of arbitrary vs semantically related image pairs, and successful vs unsuccessful memory encoding) that were then used for group conjunctions and between-group analyses.Results: Patients with FEP showed normal activation of several brain regions, including the prefrontal cortex, hippocampus, and parahippocampal cortex, during successful memory encoding and associative encoding. In contrast, the hippocampus and surrounding medial temporal areas showed reduced activity during the encoding of arbitrary pairs. This selective dysfunction reflected by abnormal brain activation during encoding was accompanied by a greater deficit for subsequent recognition of arbitrary pairs relative to the semantically related pairs.Conclusions: This study demonstrated that, in the same group of patients with FEP, the hippocampus could show either normal or abnormal modulation of activation depending on the specific cognitive process that was examined. The normal modulation of hippocampal activation observed during successful memory encoding in FEP argues against a general inability to recruit this region. Instead, the dysfunction was specifically linked to semantic relatedness. This selective deficit seems to affect memory performance in FEP and denotes an important representational problem that may confer greater vulnerability to psychotic disorders and would thus be interesting to examine in high-risk populations. Psychiatry. 2007;64(9):999-1014 Arch Gen

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Detection and localization of hippocampal activity using beamformers with MEG: A detailed investigation using simulations and empirical data

Quraan

Moses

Hung

et al. 2011

Human Brain Mapping

Self Cite

103

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The ability to detect neuronal activity emanating from deep brain structures such as the hippocampus using magnetoencephalography has been debated in the literature. While a significant number of recent publications reported activations from deep brain structures, others reported their inability to detect such activity even when other detection modalities confirmed its presence. In this article, we relied on realistic simulations to show that both sides of this debate are correct and that these findings are reconcilable. We show that the ability to detect such activations in evoked responses depends on the signal strength, the amount of brain noise background, the experimental design parameters, and the methodology used to detect them. Furthermore, we show that small signal strengths require contrasts with control conditions to be detected, particularly in the presence of strong brain noise backgrounds. We focus on one localization technique, the adaptive spatial filter (beamformer), and examine its strengths and weaknesses in reconstructing hippocampal activations, in the presence of other strong brain sources such as visual activations, and compare the performance of the vector and scalar beamformers under such conditions. We show that although a weight-normalized beamformer combined with a multisphere head model is not biased in the presence of uncorrelated random noise, it can be significantly biased in the presence of correlated brain noise. Furthermore, we show that the vector beamformer performs significantly better than the scalar under such conditions. We corroborate our findings empirically using real data and demonstrate our ability to detect and localize such sources.

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A Specific Test of Hippocampal Deficit in Schizophrenia.

Cited by 58 publications

References 82 publications

Dynamic Imaging of Deep Brain Structures with MEG: Contributions to Understanding Human Memory

Dynamic Imaging of Deep Brain Structures with MEG: Contributions to Understanding Human Memory

Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Detection and localization of hippocampal activity using beamformers with MEG: A detailed investigation using simulations and empirical data

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