A spectrophotometric method for the determination of metoclopramide HCl and dapsone

Revanasiddappa, H. D.; Manju, B.

doi:10.1016/s0731-7085(00)00592-6

Cited by 52 publications

(22 citation statements)

References 5 publications

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“…The LOD and LOQ were calculated for the same chromatographic conditions. 25 For the recovery tests for each vitamin, accurate amounts of the vitamins at high and low levels were added to approximately 1.0 g of powdered multivitamin tablet, and then the powder was extracted and analyzed. Recoveries for the spiked test samples were calculated by comparing the values to the measured recovery of the relevant control.…”

Section: Methods Validationmentioning

confidence: 99%

Simultaneous and accurate determination of water- and fat-soluble vitamins in multivitamin tablets by using an RP-HPLC method

Küçükkolbaşı¹,

Bilber²,

Ayyıldız³

et al. 2013

Quím. Nova

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Recebido em 14/10/12; aceito em 22/2/13; publicado na web em 24/5/13In the present study, a reversed-phase high-performance liquid chromatographic (RP-HPLC) procedure was developed and validated for the simultaneous determination of seven water-soluble vitamins (thiamine, riboflavin, niacin, cyanocobalamin, ascorbic acid, folic acid, and p-aminobenzoic acid) and four fat-soluble vitamins (retinol acetate, cholecalciferol, α-tocopherol, and phytonadione) in multivitamin tablets. The linearity of the method was excellent (R 2 > 0.999) over the concentration range of 10-500 ng mL −1. The statistical evaluation of the method was carried out by performing the intra-and inter-day precision. The accuracy of the method was tested by measuring the average recovery; values ranged between 87.4% and 98.5% and were acceptable quantitative results that corresponded with the label claims.

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Section: Methods Validationmentioning

confidence: 99%

Simultaneous and accurate determination of water- and fat-soluble vitamins in multivitamin tablets by using an RP-HPLC method

Küçükkolbaşı¹,

Bilber²,

Ayyıldız³

et al. 2013

Quím. Nova

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“…The method does not involve any critical reaction conditions and can be compared favourably with other existing methods [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . The proposed method can serve as an alternative method for the routine analysis of MCP and DAP in pure drugs and in pharmaceutical formulations.…”

Section: Discussionmentioning

confidence: 99%

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Revanasiddappa¹,

Veena²

2006

ScienceAsia

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A simple, sensitive and selective spectrophotometric method for the determination of metoclopramide hydrochloride (MCP) and dapsone (DAP) in both pure and dosage forms is described. The method is based on the diazo -coupling reaction of the studied drugs with a new coupling agent, imipramine hydrochloride, in an acid medium. The resulting violet -colored azo dyes exhibit maximum absorption at 570 nm for both MCP and DAP. All variables were studied in order to optimize the reaction conditions. The method is suitable for the determination of MCP and DAP in the presence of other ingredients that are usually present in dosage forms and the recoveries were obtained in the range of 99.5-100.5%. The results are reproducible with an accuracy of ±1%, and the validity of the method was tested against reference method.

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“…These spectrophotometric procedures include derivative spectrophotometric [19,20], UV spectrophotometric [21][22][23] and sequential injection spectrophotometric [24,25]. Several spectrophotometric methods based on diazo-coupling reaction [26][27][28][29][30][31][32][33][34][35][36], Schiff`s base reaction [36][37][38][39], ion-pair complex reaction [40,41], charge-transfer reaction [42,43] and redox reaction [44,45] were described. Also, spectrofluorimetric methods for MCP determination were suggested [46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

AH¹,

TAS²,

AS³

2017

Pharm Anal Acta

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Three simple, selective, accurate and precise spectrophotometric methods were developed for the determination of Metoclopramide Hydrochloride (MCP) in dosage forms. The first method (Method A) is based on coupling reaction of diazotized MCP with 2,5-diphenyl-2,4-dihydro-pyrazol-3-one (DPP) in alkaline medium to form azo dye. The second method (Method B) is based on Schiff's base formation reaction between MCP and 4-hydroxybenzaldehyde (HBD). The last method (Method C) is based on the formation of colored ion-pair complex from the reaction of MCP with Eosin Y (ESN). Beer's law was obeyed in the concentration range of 1.35-40.37, 1.01-5.05 and 1.01-10.09 µg/mL MCP at 426, 386 and 543 nm with molar absorptivity of 1.51×10 4 L mol -1 cm -1 , 2.10×10 4 L mol -1 cm -1 and 3.34×10 4 L mol -1 cm -1 for Method A, Method B and Method C, respectively. The proposed methods were successfully applied to the determination of MCP in pharmaceutical preparations without any interference from common excipients.

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A spectrophotometric method for the determination of metoclopramide HCl and dapsone

Cited by 52 publications

References 5 publications

Simultaneous and accurate determination of water- and fat-soluble vitamins in multivitamin tablets by using an RP-HPLC method

Simultaneous and accurate determination of water- and fat-soluble vitamins in multivitamin tablets by using an RP-HPLC method

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Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

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