A splenic hamartoma: Adding a new case to the literature: A case report

Sabra, Tarek Abdelazeem; Maher, Ahmed; AlRashidi, Rahf; Ibrahim, Hassan

doi:10.1016/j.ijscr.2021.106647

Cited by 6 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, lymphoid follicles are characteristically not present [ 20 ]. CD8-positivity (a T cell marker), which entails a splenic sinusoidal origin, helps distinguish this entity from the more common hemangioma, which only shows positivity for endothelial markers such as CD 34 and factor VIII-related antigen [ 7 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Splenic Hamartoma: A Case Report and Literature Review

et al. 2022

View full text Add to dashboard Cite

Patient: Male, 19-year-old Final Diagnosis: Splenic hamartoma Symptoms: Abdominal pain Medication:— Clinical Procedure: Laparoscopic splenectomy Specialty: Surgery Objective: Rare disease Background: Splenic hamartoma (SH) is a benign vascular lesion, usually found incidentally on abdominal images or at autopsy. Only around 200 cases have been reported since 1861, when SH was first described by Rokitansky. Although it is very rare, it is important to be familiar with it, as it may be a diagnostic challenge to distinguish SH from other mass lesions of the spleen based solely on preoperative investigations. Case Report: We describe a case of symptomatic, isolated, single splenic hamartoma in a 19-year-old, otherwise healthy young man who presented with upper abdominal pain, nausea, and vomiting for a few months. The examination was unremarkable. The patient has been previously evaluated with abdominal ultrasonography, which found a suspicious splenic hyperechoic lesion. Computed tomography revealed a heterogeneous 5×7 cm enhancing lesion in the spleen, concerning for splenic hamartoma. The patient underwent laparoscopic splenectomy and recovered well. The histopathology examination confirmed the diagnosis of splenic hamartoma. Conclusions: Splenic hamartoma is a rare benign vascular lesion of debated etiology. Most cases are asymptomatic and are found incidentally on images, in splenectomies performed for other reasons, or at autopsy. Radiologic findings may suggest the diagnosis and new modalities have shown accuracy in distinguishing splenic hamartomas. However, resection with formal or partial splenectomy is usually still needed since the differential diagnosis is wide, from benign to aggressive lesions, and histopathology remains the criterion standard for diagnosis. Given its benign nature, we found no cases of recurrence or metastasis in the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Splenic Hamartoma: A Case Report and Literature Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Partly because of the low frequency and morphologic overlap between these lesions, it is difficult to distinguish from each other. Some authors observed that SANT were often accompanied with primary splenic lesions including splenic hamartoma 3,11,12 , inflammatory pseudotumor 13,14 , hemangioma 15,16 . Thus, they presumed that SANT was developed from those tumors.…”

Section: Discussionmentioning

confidence: 99%

Clonality analysis of Sclerosing Angiomatoid Nodular Transformation in Spleen

Han

Chen³

et al. 2022

Preprint

View full text Add to dashboard Cite

Aims: Use clonality study to detect sclerosing angiomatoid nodular transformation (SANT) of the spleen and to explore the essence and pathogenesis of SANT.Methods: All SANT cases was performed by clonality analysis and in situ hybridization for the presence of EBV encoded small RNAs (EBER). Immunohistochemisty were used to classify the character of SANT, hemangioma. Results: The results of histological and immunohistochemical detection show the obstruction of arterioles and the passive congestion of venules in red pulp might participate in the formation of SANT. The results of clonality analysis show polyclonality was demonstrated in SANT nodules and the surrounding spleen parenchyma.Conclusion: SANT is a benign proliferative lesion. Combined with the immunohistochemisty, clonality analysis can be an useful tool for differential diagnosis of these splenic lesions.

show abstract

“…Data were collected on age, sex, number, size, and location of hamartomatous nodules, clinical signs and symptoms, laboratory findings, imaging, indication for surgery, type of operation, and outcomes. The search revealed 47 cases described as SH in children[ 5 , 6 , 8 , 11 - 33 ].…”

Section: Literature Searchmentioning

confidence: 99%

“…SH may be a diagnostic challenge because it is often asymptomatic or presents with non-specific symptoms and has no pathognomonic radiological appearance. Therefore, histopathological analysis represents the cornerstone of correct diagnosis[ 2 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Splenic hamartomas in children

Milickovic,

Rasic,

Cvejic

et al. 2024

World J Clin Cases

View full text Add to dashboard Cite

Splenic hamartomas (SHs) are uncommon, benign vascular lesions of unclear etiology and are mostly found incidentally on abdominal images, at surgery, or at autopsy. Since the first case description, in 1861, less than 50 pediatric SH cases have been reported in the literature. In this article, we have performed an analysis of all SH cases in children published in the literature to date and presented our case of an 8-year-old male with SH. These lesions in children were shown to cause symptoms more often than in the adult population. The observed SH sizes in children ranged from a few millimeters to 18 cm, and the symptomatic lesions were mostly larger or multiple. The most common clinical finding was splenomegaly. Signs of hypersplenism were present in children with a single SH larger than 4.5 cm (diameter range: 4.5-18.0 cm) and in those with multiple hamartomas, ranging from a few millimeters to 5 cm. Eighty percent of patients with available laboratory findings had hematological abnormalities such as anemia, thrombocytopenia, or pancytopenia. Other symptoms and signs included abdominal pain, recurrent infections, fever, night sweats, lethargy, growth retardation, and weight loss. The use of multiple imaging modalities may suggest the preoperative diagnosis of a splenic mass in children and determine the therapeutic approach. However, the final diagnosis of SH relies on histopathological evaluation. Surgery, including total or partial splenectomy (PS), is the mainstay of SH management. Although total splenectomy carries a greater risk of overwhelming post-splenectomy infection than PS it has remained the most performed surgical procedure in children with SH. In the majority of pediatric patients with symptomatic SH, resolution of symptoms and resolution or improvement of cytopenias occurred after surgical treatment.

show abstract

A splenic hamartoma: Adding a new case to the literature: A case report

Cited by 6 publications

References 16 publications

Splenic Hamartoma: A Case Report and Literature Review

Splenic Hamartoma: A Case Report and Literature Review

Clonality analysis of Sclerosing Angiomatoid Nodular Transformation in Spleen

Splenic hamartomas in children

Contact Info

Product

Resources

About