2018
DOI: 10.7897/2230-8407.09575
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A Stability-Indicating HPLC Method for the Determination of Potential Impurities in a New Fixed Dose Combination of Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate Tablets Used in the First Line Treatment of Hiv-1 Infection

Abstract: Developing a single method for the quantification of related compounds for a combination product containing three active ingredients is difficult task. Separation and compromising run time to elute all known and unknown degradation products are crucial for a combination product. The aim of current work is to develop a new stability indicative method and validate for a fixed dose combination product containing dolutegravir, lamivudine, tenofovir disoproxil fumarate and their potential impurities in a single run… Show more

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Cited by 6 publications
(2 citation statements)
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“…Many RP-HPLC procedures were available for simultaneous determination of LAM, EVZ, and TDF in combined tablets [12][13][14][15][16][17][18][19]. But no RP-HPLC method was subsisted with a simple solvent system, and less retention time existed.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Many RP-HPLC procedures were available for simultaneous determination of LAM, EVZ, and TDF in combined tablets [12][13][14][15][16][17][18][19]. But no RP-HPLC method was subsisted with a simple solvent system, and less retention time existed.…”
Section: Discussionmentioning
confidence: 99%
“…The broad literature search disclosed that a small number of analytical methods like UV and RP-HPLC methods were at hand for determination of LAM. TDF and EVZ individually and in combined dosage form [3,5,[12][13][14][15][16]. In addition to those methods, few RP-HPLC methods were described for determination of LAM, TDF with dolutegravir, and other antiviral agents [17][18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%