A statistical mechanics investigation of unfolded protein response across organisms
Nicole Luchetti,
Keith M. Smith,
Margherita A. G. Matarrese
et al.
Abstract:Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical threshold. It maintains cell homeostasis by enhancing protein folding, initiating quality control, and activating degradation pathways when damage is irreversible. This response functions as a dynamic signaling network, with proteins as nodes and their interactions… Show more
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