A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo

Lecanu, Laurent; Hashim, Areej I.; McCourty, Althea; Papadopoulos, Vassilios

doi:10.1016/j.steroids.2011.11.009

Cited by 3 publications

(1 citation statement)

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“…Many natural compounds have been studied in these last years because of they are able to affect not only cell differentiation of solid tumors as chondrogenesis [67] and neuronal cells [68], but also of bone marrow-derived hematopoietic cells. Although the main differentiation inducer in acute promyelocytic leukemia therapy has been all-trans retinoic acid (ATRA), these compounds can support traditional anticancer chemotherapies or enhance the effect of ATRA [69].…”

Section: Differentiation Inducers In Aml and CMLmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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Section: Differentiation Inducers In Aml and CMLmentioning

confidence: 99%