Purpose: The theory of constraints (TOC) drum-buffer-rope methodology is appropriate when managing a production plant in complex environments, such as make-to-order (MTO) scenarios. However, some difficulties have been detected in implementing this methodology in such changing environments. This case study analyses a MTO company to identify the key factors that influence the execution of the third step of TOC. It also aims to evaluate in more depth the research started by Lizarralde et al. (2020) and compare the results with the existing literature.Design/methodology/approach: The case study approach is selected as a research methodology because of the need to investigate a current phenomenon in a real environment.Findings: In the case study analysed, the protective capacity of non-bottleneck resources is found to the key factor when subordinating the MTO system to a bottleneck (BN). Furthermore, it coincides with one of the two key factors defined by the literature, namely protective capacity and protective inventory.Originality/value: The three key contributions of this study focus on the MTO environment as follows. The first is about identifying the key factors in subordinating the system to the BN (step 3, TOC) according to the existing literature which have been identified through a systematic literature review. The second focuses on identifying the key factors in subordinating the system to the BN through a case study. Finally, the last contribution compares the results obtained in the case study with those obtained in the literature review.