A Strategy for the Control of Endometrial Cancer

Gusberg, S.B.

doi:10.1177/003591577506800308

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…In the obese patients, the mean plasma estrogen was 104.87 ng/100 ml, SE 10.75, which is No 5 PLASMA ESTROGENS IN ENDOMETRIAL CARCINOMA Aleem et al…”

Section: Endometrial Carcinomamentioning

confidence: 99%

Plasma estrogen in patients with endometrial hyperplasia and carcinoma

Aleem

Moukhtar

Hung

et al. 1976

Cancer

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In a total of 53 patients, most of whom were over 40 years of age and who presented symptoms of vaginal bleeding, total plasma estrogens were measured with gas liquid chromatography, and the clinical correlates were studied. The results revealed that total plasma estrogen levels in the endometrial hyperplasia and endometrial carcinoma groups were significantly higher than those measured in the control group. In addition, a positive, significant correlation was found between the plasma estrogen levels and obesity in the patients with endometrial carcinoma. The study provides objective data that document the clinical impressions that hyperestrogenism and obesity are significant findings in endometrial carcinoma.

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“…In the obese patients, the mean plasma estrogen was 104.87 ng/100 ml, SE 10.75, which is No 5 PLASMA ESTROGENS IN ENDOMETRIAL CARCINOMA Aleem et al…”

Section: Endometrial Carcinomamentioning

confidence: 99%

Plasma estrogen in patients with endometrial hyperplasia and carcinoma

Aleem

Moukhtar

Hung

et al. 1976

Cancer

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“…These conditions are related by a tendency toward an unopposed action of estrogen on the endometrium (3,4). Endometrial carcinoma is thought to progress through a sequence of stages leading from normal proliferation, benign hyperplasia, atypical hyperplasia and then an irreversible transformation to invasive carcinoma (5,6). As an example of the clinical importance of these considerations, endometrial carcinoma was diagnosed in a premenopausal woman with chronic anovulation due to therapy for systemic lupus erythematosus.…”

Section: Introductionmentioning

confidence: 99%

Endometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus

Sekiya

Iwasaki

Takeda

et al. 1988

Acta Obstet Gynecol Scand

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Endometrial carcinoma was diagnosed in a premenopausal woman suffering with systemic lupus erythematosus. She had received both prednisolone and an immunosuppressive agent for more than 10 years. Anovulatory cycles persisted during drug administration, along with dysfunctional uterine bleeding. The serum estrogen: progesterone ratio was high. Repeated endometrial biopsies revealed a progression of change from benign proliferation to cystic hyperplasia, adenomatous hyperplasia, atypical hyperplasia and invasive adenocarcinoma. These clinical data suggest that a result of long-term unopposed endogenous estrogen can have been the cause of the endometrial carcinoma.

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Biology of female sex hormone action in relation to contraceptive agents and neoplasia

King

1991

Contraception

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A Strategy for the Control of Endometrial Cancer

Cited by 5 publications

References 32 publications

Plasma estrogen in patients with endometrial hyperplasia and carcinoma

Plasma estrogen in patients with endometrial hyperplasia and carcinoma

Endometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus

Biology of female sex hormone action in relation to contraceptive agents and neoplasia

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