A Structurally Diverse Heterocyclic Library by Decoration of Oxcarbazepine Scaffold

Abstract

A library of new heterocyclic systems was synthesized starting from oxcarbazepine (OXC, Trileptal ® , 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide). The key for these transformations is the α-enolizable ketone present on the [d]-side of our starting material OXC, thus, an in depth investigation of the literature to find heteroannulation reactions for substrates carrying an α-enolizable ketone gave us a boost to discover an excellent derivatization strategy and [3+2], [4+2] and [4+1] approaches were successfully developed. Almost always a pre-functionalization was needed, but also the direct one-pot heterocycle construction was also explored.

Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles

“…Gels 2021, 7, x FOR PEER REVIEW 3 of 14 compounds [57][58][59][60], we prepared a set of bi-and trifunctional tetrazoles and applied them for the first time in the photoinduced cross-linking of porcine skin gelatin.…”

“…However, it may be ideal as an effective cross-linking strategy to achieve improvements in the macroscopic characteristics of biological materials, such as gelatin. Intrigued by this possibility and exploiting our expertise in the synthesis of heterocyclic compounds [57][58][59][60], we prepared a set of bi-and trifunctional tetrazoles and applied them for the first time in the photoinduced cross-linking of porcine skin gelatin.…”

Theoretical Study of the Geometry of Dibenzoazepine Analogues

“…The first effective drug for such ailments was imipramine [3]. Thanks to the interest in this group of compounds, further 10,11-dihydro-5H-dibenzo[b,f]azepine derivatives were created [4][5][6] expecting them to be drugs as well. Navdeep Kaur synthesized a series of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates, which may have a positive effect on the treatment of cognitive vascular disorders [4].…”

A novel porphyrazine ligand tailored to homogeneous metal catalyzed transformations

“…Thus, a survey of oxidants was undertaken and on treatment of 2 with freshly sublimed SeO 2 (2.5 equiv) in refluxing 1,4-dioxane for 7 h, clean tandem oxidation/N-decarbamoylation pleasingly ensued to produce 3 in 90% yield. 13,14 This compound precipitates directly from the reaction mixture as orange solid so that this process proved useful enough to prepare multigram quantities of 3. In the approach to 3, alternatives to Scheme 2 were examined which proved less successful or less direct.…”