A Study of Association between Diabetes Mellitus and Chronic Hepatitis B Virus Infection

Khurshid, Mohsin; Rashid, Abdur; Aslam, Nosheen; Najam, Syeda Sadia; Siddique, Tanjir Tarek Ibn; Islam, Muhammad Tarikul; Zain, Mollyza Mohd; Khan, Ali Raza; Shah, A. A.; Awan, Fazli Rabbi

doi:10.7727/wimj.2015.236

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 20 (12,13,14,15,16,17,18,19,21,22,23,24,25,26,27,28,29,30,31,32) studies were analyzed with 245,468,411 subjects were enrolled this study which were published between 2003 to 2020. In which divided into two subgroups, 12,982,158 patients with HBV infected group and 232,486,253 patients in non infected HBV groups.…”

Section: Figure 2 Outlines the Characteristics Of Included Studiesmentioning

confidence: 99%

Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies

Sari

Agdelina

Bahri

et al. 2021

InaJGHE

View full text Add to dashboard Cite

Background: There are a lot of theories about how Hepatitis B Virus (HBV) infection affects many diseases, one of them is Diabetes Mellitus (DM). However, the relation remains controversial between DM and HBV as an infection. This study aims to evaluate HBV infection as a risk factor for developing DM.Method: A systematic review was performed using medical search engines such as Pubmed, ScienceDirect and GoogleScholar. References until February 2021 that met the inclusion criteria were reviewed. The primary outcome was the prevalence of DM. Authors also perform Subgroup analyses based on study type. The extracted data were analyzed using RevMan 5.4 application.Results: A total of 20 studies were analyzed with 245,468,411 subjects included. In which divided into two groups, patients with HBV infected group and non infected HBV group. Authors found that there is a statistically difference between patients with HBV infected groups and non infected HBV groups on the primary outcome which is the prevalence of DM (OR 1.24; 95% CI, 1.10-1.41; p = 0.0006). Authors also found the same results based on study type both in case-control (OR = 1.76; 95% CI: 1.08-2.85; p = 0.02) and cross-sectional (OR = 1.40; 95% CI: 1.05-1.85; p = 0.02) studies. Meanwhile in Cohort studies the results show no statistically significant difference between the two groups (OR = 1.07; 95% CI: 0.87-1.33; p = 0.52). Conclusion: HBV infected patients have a higher risk of developing DM than patients without HBV infection.

show abstract

Section: Figure 2 Outlines the Characteristics Of Included Studiesmentioning

confidence: 99%

Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies

Sari

Agdelina

Bahri

et al. 2021

InaJGHE

View full text Add to dashboard Cite

show abstract

“…Hyperglycemia is a symptom of diabetes, which is induced by insufficient, or lack of, insulin secretion [ 1 , 2 ]. In diabetic patients, chronic hyperglycemia may be associated with the failure, damage and dysfunction of various body organs [ 3 , 4 ]. It primarily affects the kidneys (nephropathy), heart via cardiovascular diseases, blood vessels, eyes (retinopathy) and nerves (neuropathy) [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential

et al. 2022

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a metabolic disease caused by improper insulin secretion leading to hyperglycemia. Syzygium cumini has excellent therapeutic properties due to its high levels of phytochemicals. The current research aimed to evaluate the anti-diabetic potential of S. cumini plant’s seeds and the top two phytochemicals (kaempferol and gallic acid) were selected for further analysis. These phytochemicals were selected via computational tools and evaluated for α-Glucosidase inhibitory activity via enzymatic assay. Gallic acid (IC50 0.37 µM) and kaempferol (IC50 0.87 µM) have shown a stronger α-glucosidase inhibitory capacity than acarbose (5.26 µM). In addition, these phytochemicals demonstrated the highest binding energy, hydrogen bonding, protein–ligand interaction and the best MD simulation results at 100 ns compared to acarbose. Furthermore, the ADMET properties of gallic acid and kaempferol also fulfilled the safety criteria. Thus, it was concluded that S. cumini could potentially be used to treat DM. The potential bioactive molecules identified in this study (kaempferol and gallic acid) may be used as lead drugs against diabetes.

show abstract

A Study of Association between Diabetes Mellitus and Chronic Hepatitis B Virus Infection

Cited by 2 publications

References 0 publications

Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies

Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies

Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential

Contact Info

Product

Resources

About