A study of cluster behavioral abnormalities in down syndrome

Bhattacharyya, Ranjan; Sanyal, Debasish; Roy, Krishna; Saha, Sudipta

doi:10.4103/0019-5359.49232

Cited by 7 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An opposite profile emerged in the group with DS, mainly characterized by Oppositional Defiant disorder (10.7%). Our results are consistent with previous studies examining separately the two groups and confirm that individuals with WS may be at risk for developing ADHD while individuals with DS may be at risk for developing Oppositional Defiant disorder and Conduct disorder [9,47,[64][65][66].…”

Section: Discussionsupporting

confidence: 92%

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Vicari¹,

Costanzo²,

Arm³

et al. 2016

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

The occurrence and co-occurrence of psychiatric disorders have been more frequently reported in people with Intellectual Disability (ID) than in the general population. The present study was aimed at verifying whether the psychiatric profile of individuals with ID is just a consequence of ID or derives from a specific genotype. The psychiatric profile of 112 individuals with Down syndrome (DS) and 85 with Williams syndrome (WS) was examined. The interactions between psychiatric symptom clusters and the effect of age were also investigated.Participants with WS had higher rates of psychiatric disorders, and, specifically, of Anxiety disorders and Psychosis than DS. However, the psychiatric profile changed by age, since Anxiety disorder was higher in individuals with WS compared to DS in young age, while Psychosis in old age. A relation between the occurrence of disorders, as Anxiety disorder and Mood Disorder, was found only in participants with WS. Moreover, distinct Anxiety and Behavior Disorder subtypes emerged between groups.Results indicate that the genetic etiology of ID differently affects the psychiatric characteristics of the groups and suggest the importance of a targeted psychiatric care for individuals with WS and DS.

show abstract

Section: Discussionsupporting

confidence: 92%

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Vicari¹,

Costanzo²,

Arm³

et al. 2016

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

show abstract

“…[27] found that contrary to the conventional belief, individuals diagnosed with Down syndrome had higher frequency of behavioral abnormalities such as impulsivity and stereotypies compared to the normal population.…”

Section: Mental Retardation and Comorbiditymentioning

confidence: 99%

Indian research on comorbidities

Srivastava

Sreejayan

Joseph

et al. 2010

Indian J Psychiatry

View full text Add to dashboard Cite

The objective of this paper is to provide a review on the psychiatric comorbidity research in India based on the data published in the last six decades. The comorbidity data world over reflects that it is a much more common phenomenon than observed in routine clinical practice. In India, research into this domain of psychiatry has been limited, with comorbidity reported to be as high as 60%. In the few publications in this area, most of the authors have looked into substance related comorbidity. Small numbers of studies have looked into comorbid conditions in child psychiatry, especially mental retardation and very few studies have looked at other comorbidities. The landmarks in the studies in the area of psychiatric comorbidity have been highlighted in this review article.

show abstract

“…Compared with TD controls, 4-year-old to 18-year-old individuals with DS are more likely to show externalizing behaviours related to ADHD, OCD and conduct disorder Coe et al, 1999;Bhattacharyya et al, 2009). Indeed, 6-8% of children with DS are diagnosed with ADHD and 10-15% of children or adolescents are diagnosed with conduct or oppositional disorders (Gath and Gumley, 1986;Myers and Pueschel, 1991;Coe et al, 1999).…”

Section: Attention Deficit Hyperactivity Disorder and Externalizing Bmentioning

confidence: 99%

Neurodevelopmental and psychiatric issues in Down’s syndrome

Vicari

Pontillo

Armando

2013

Psychiatric Genetics

View full text Add to dashboard Cite

Down's syndrome (DS) is the most frequent genetic cause of intellectual disability and patients with DS show significant psychopathology (18-23%). Moreover, individuals with DS often show a cognitive decline associated with ageing characterized by a deterioration in memory, language and cognitive functioning. According to these relevant findings, an overview is presented of state-of-the-art knowledge of the neurocognitive, neurobiological and psychopathological profile, assessment and treatment of patients with DS. The linguistic characteristics of DS develop differently along distinct developmental trajectories. Thus, for example, morphosyntax deficit, especially in production, is more evident in adolescence than in early childhood and lexicon is usually better preserved in all ages (at least in comprehension). So far, rehabilitation is the only effective approach for improving cognitive and linguistic abilities. However, ongoing preliminary reports on other approaches such as transmagnetic stimulation or drugs suggest alternative or integrative treatment for the future. Individuals with DS show typical organization of brain structures related to some cognitive abilities, such as reduced volume in frontal and prefrontal areas, which is related to poor executive and linguistic abilities. They also frequently show psychiatric disorders such as externalizing disorders as well as depression, anxiety and obsessive-compulsive disorder. Nevertheless, as for other genetic syndrome with intellectual disability, there is a significant lack of research specifically focused on treatments of psychiatric and behavioural problems in DS. This is true both for psychosocial and for pharmacological interventions.

show abstract

A study of cluster behavioral abnormalities in down syndrome

Cited by 7 publications

References 22 publications

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome

Indian research on comorbidities

Neurodevelopmental and psychiatric issues in Down’s syndrome

Contact Info

Product

Resources

About