A study of collagen-based bioactive dressings

Abstract

Laboratory studies of collagen-based compositions demonstrated digispon to be the most effective agent for clinical use. Digispon is permeable to vapor and air, plastic, ensures prolonged dosed release of dioxydine into the wound, stimulates the growth of granulation tissue, accelerates marginal and islet epithelialization, and reduces the likelihood of the formation of coarse scar tissue. Radioautographic study of wound granulation tissue in experimental animals with modeled nonsuppurative inflammation showed that the principal processes ensuring wound healing during the application of collagen-based agents occur in the early stages, with an increase in the number of fibroblasts, including the proliferating variety, and blood vessels.

Specific effect of epidermal growth factor immobilized on wound coating with soluble collagen on healing of experimental wounds

“…Hence, partial lysis of exogenous collagen resulted in local prolonged release of EGF acting as a mitogen, i. e. factor inducing cell proliferation. Collagen degradation products also stimulated activity of cell elements and were utilized as plastic material for newly formed connective tissue [ 1 ].…”