A study of environmental factors in cancer of the larynx

Wynder, Ernest L.; Bross, Irwin D. J.; Day, Emerson

doi:10.1002/1097-0142(195601/02)9:1<86::aid-cncr2820090108>3.0.co;2-6

Cited by 170 publications

(49 citation statements)

References 18 publications

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“…Many other workers have described similar findings (Wynder et al, 1956(Wynder et al, , 1976Vincent & Marchetta, 1963;Rothman & Keller, 1972;Feldman & Hazan, 1975;McMichael, 1978;Ward Hinds et al, 1979). Another neoplasm which has been consistently related to heavy smoking is lung cancer; a comparative study of lung and larynx cancer in relation to tobacco and alcohol consumption is thus of interest.…”

supporting

confidence: 57%

The role of tobacco and alcohol in the aetiology of lung and larynx cancer

Herity¹,

Moriarty²,

Daly³

et al. 1982

Br J Cancer

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supporting

confidence: 57%

The role of tobacco and alcohol in the aetiology of lung and larynx cancer

Herity¹,

Moriarty²,

Daly³

et al. 1982

Br J Cancer

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“…The mean time since the last visit was 12-5 years for the cases and 14 years for controls. (Wynder et al, 1956;1976) and in Australia and Great Britain (McMichael, ** 1978). Since most head and neck tumours have an induction period of up to 30 years, ted.…”

Section: Combined Effect Of Tobacco and Alcohcmentioning

confidence: 99%

“…Many studies (Wynder et al, 1956;Feldman & Hazan, 1975;Jayant et al, 1977;Simarak et al, 1977;McMichael, 1978;Ward Hinds et al, 1979) Wynder et al (1976) showed that at each measure of cigarette consumption heavy alcohol consumption increased the risk of laryngeal cancer, but no such increased risk was seen in non-smoking heavy drinkers. The findings of Feldman & Hazan (1975) were similar, but a significant synergistic effect between tobacco and alcohol was not demonstrated.…”

Section: Combined Effect Of Tobacco and Alcohcmentioning

confidence: 99%

“…MANY STUDIES (Wynder et al, 1956;1976;Vincent & Marchetta, 1963;Rothman & Keller, 1972;Feldman & -Hazan, 1975;McMichael, 1978;Ward Hinds et al, 1979) have demonstrated a positive association between the consumption of tobacco and alcohol and the development of head and neck tumours. The 1979 Surgeon General's Report included references to studies in many parts of the world which show that the use of tobacco in all its forms is a risk factor in oral and laryngeal cancers.…”

mentioning

confidence: 99%

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A case-control study of head and neck cancer in the Republic of Ireland

Herity¹,

Moriarty²,

Bourke³

et al. 1981

Br J Cancer

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Summary.-A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and the association of smoking with laryngeal cancer and of alcohol with cancer of the tongue was particularly strong. A significant excess of alcohol-related occupations was found among the cases. These findings are discussed.

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“…The most important of these are factors related to sexual behaviour and elevated risks have been associated with multiple sexual partners and having been divorced (Boyd & Doll, 1964;Martin, 1967;Harris et al, 1980;Rawls et al, 1986;Brinton et al, 1987), early age at first intercourse (Wynder et al, 1954;Rotkin, 1973;La Vecchia et al, 1986), marriage (Martin, 1967;Rotkin, 1967) or first childbirth (Boyd & Doll, 1964;Harris et al, 1980) and high parity (Jussawalla et al, 1971;Brinton et al, 1987). These observations all point to the existence of a venereally transmitted causative agent (Beral, 1974) and there is now much evidence to indicate that certain types of the human papilloma virus (HPV) have a central role in this process.…”

mentioning

confidence: 99%

A case-control study of cervix cancer in Singapore

Cuzick

Stavola²,

McCance³

et al. 1989

Br J Cancer

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Summary Cervix cancer is about twice as common in Asia as in the Western world and its incidence varies among different Asian ethnic groups. A study based in Singapore, the population of which comprises Chinese, Indians and Malaysians, offers the opportunity to evaluate whether the same risk factors are important in this part of the world as in the West.A total of 135 cases and an equal number of controls were interviewed and details concerning reproductive and sexual history, smoking, hygiene, socio-economic status and education were collected. Seventy-three cases had invasive cancer while 62 had micro-invasive disease or CIN III. The most important risk factors were parity and number of sexual partners. Smoking was rare in cases and controls and did not appear to be an important determinant of risk. Of the socio-economic factors, education appeared most predictive and lowered the risk. Age at first intercourse was strongly correlated with education (positively) and parity (negatively), but not with number of sexual partners. Biopsies were available for HPV DNA analysis in 38 cases and 37% were positive, mostly for HPV type 16. All these factors gave similar risks in invasive and preinvasive disease.A fairly consistent picture of risk factors for cervical cancer is now emerging from studies in Western Countries (Cramer, 1982). The most important of these are factors related to sexual behaviour and elevated risks have been associated with multiple sexual partners and having been divorced

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A study of environmental factors in cancer of the larynx

Cited by 170 publications

References 18 publications

The role of tobacco and alcohol in the aetiology of lung and larynx cancer

The role of tobacco and alcohol in the aetiology of lung and larynx cancer

A case-control study of head and neck cancer in the Republic of Ireland

A case-control study of cervix cancer in Singapore

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