A Study of Facial Pattern in Patients With Fanconi's Anemia

Martins, Wilson; Fátima, Lúcia de; Ávila, Castro; Ribas, Marina de Oliveira; Cândido, Lisiane; Ignácio, Sérgio Aparecido; Bonfim, Carmen

doi:10.1597/11-321

Cited by 2 publications

(3 citation statements)

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“…18 The other alterations may be justified by craniofacial anomalies such as microcephaly and micrognathia. 19 In the present case, mandibular mesiodens was seen, which is an extremely rare occurrence with an incidence of 0.01%. 20 Delayed eruption and shedding of teeth were also present.…”

Section: Discussionmentioning

confidence: 45%

Dental Perspective of Rare Disease of Fanconi Anemia: Case Report with Review

Goswami

Bhushan

Goswami³

2016

Clin Med Insights Case Rep

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Fanconi anemia is an extremely rare genetic disease characterized by chromosomal instability that induces congenital alterations in individuals. It causes defective hemopoiesis ultimately leading to bone marrow failure. Patients are susceptible to recurrent infections and increased risk of hemorrhage, as well as delayed and poor wound healing. Herein, we report a case of Fanconi anemia in which various classical signs of the disease were present. The patient has been on regular follow-up since three and a half years for management of dental problems. The different aspects of this rare disorder are discussed with emphasis on oral manifestations and their influence on the general health of affected patients. Due to an increased susceptibility to developing cancers in this specific population, it is imperative for pediatric dentists to know about the common oral manifestations and potentially cancerous lesions, in order to make an early diagnosis and provide comprehensive care and maintenance of oral health in affected individuals.

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Section: Discussionmentioning

confidence: 45%

Dental Perspective of Rare Disease of Fanconi Anemia: Case Report with Review

Goswami

Bhushan

Goswami³

2016

Clin Med Insights Case Rep

View full text Add to dashboard Cite

show abstract

“…Alterations in calcium metabolism during odontogenesis related to Vitamin D resistant rickets, explain some of the dental alterations in individuals with FA, such as agenesia and presence of supernumerary teeth 13 . The other alterations may be justified by the cranio-facial anomalies such as microcephaly and retro/micrognathia 38 . Discrepancy between dental, chronological and bone age in individuals with FA is relevant, since the dental and bone age are lower than the chronological age 39 .…”

Section: Dental Anomaliesmentioning

confidence: 99%

“…Furthermore, it is common for these patients to present low stature, growth hormone deficiency and hypothyroidism. This may occur due to hypoactivity of the hypothalamus causing insufficiency of growth hormone, resistance to its action and hypothyroidism 38 .…”

Section: Dental Anomaliesmentioning

confidence: 99%