A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression

Fitzgerald, Paul B.; Mellow, Tessa; Hoy, Kate Elizabeth; Segrave, Rebecca; Cooper, Nicholas R.; Upton, Daniel J.; Croft, Rodney J.

doi:10.1016/j.jad.2009.01.009

Cited by 48 publications

(20 citation statements)

References 16 publications

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“…In addition, a weak LDAEP reflects high serotonergic neurotransmission in the central nervous system [8], [9]. There was some evidence that LDAEP can be a useful tool in patients with MDD [10], [11], [12], [13]. In addition, it was found that depressed patients with higher LDAEP showed better treatment response to SSRIs [7], [14], [15], [16], [17], [18].…”

Section: Introductionmentioning

confidence: 99%

Serum BDNF Levels in Relation to Illness Severity, Suicide Attempts, and Central Serotonin Activity in Patients with Major Depressive Disorder: A Pilot Study

Park

Lee

et al. 2014

PLoS ONE

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The aim of this study was to test the hypothesis that serum levels of brain-derived neurotrophic factor (BDNF) are correlated with the loudness dependence of auditory evoked potentials (LDAEP). The question of whether there is a difference in BDNF levels between depressive patients according to their illness severity, history of suicide attempts, and central serotonin activity was also addressed. A sample of 51 patients who met the criteria for major depressive disorder following diagnosis using axis I of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders – text revision comprised the study subjects. The patients were stratified into two subgroups based on their illness severity, history of suicide attempts, and their LDAEP values. The LDAEP was evaluated by measuring the auditory event-related potentials, and serum BDNF was measured using blood sampling before beginning medication with serotonergic agents. There was no difference in serum BDNF levels between the two patient subgroups. The subgroup with moderate-to-severe depression (n = 16) was reanalyzed after stratifying it into two subgroups according to LDAEP and BDNF values (dichotomized at the medians into low and high). The high-LDAEP subgroup had higher serum BDNF levels and total Barratt Impulsiveness Scale score than the low-LDAEP subgroup (p = 0.03 and 0.036, respectively). Serum BDNF levels were positively correlated with LDAEP and total Beck Hopelessness Scale (BHS) score (r = 0.56, p = 0.025, and r = 0.59, p = 0.016, respectively). The high-BDNF subgroup had a higher LDAEP and total BHS score than the low-BDNF subgroup (p = 0.046 and p = 0.011, respectively). This is the first study to demonstrate a relationship between the BDNF level and LDAEP in Asian depressive patients. Intriguingly, the high-BDNF subgroup (divided according to illness severity) exhibited a more severe psychopathology on some psychometric rating scales, a finding that conflicts with previous results.

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Section: Introductionmentioning

confidence: 99%

Serum BDNF Levels in Relation to Illness Severity, Suicide Attempts, and Central Serotonin Activity in Patients with Major Depressive Disorder: A Pilot Study

Park

Lee

et al. 2014

PLoS ONE

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“…Though greater N1/P2 amplitudes with increased intensity and steeper LDAEP slopes have been noted in MDD (Gopal et al, 2004; Manjarrez-Gutierrez et al, 2009), suggesting inefficient 5-HT neurotransmission, others have found no such alterations (Linka et al, 2007; Park et al, 2010). Additionally, LDAEP slope modulations may to be associated with specific MDD subtypes and features (Chen et al, 2005; Fitzgerald et al, 2009; Linka et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Response prediction to antidepressants using scalp and source-localized loudness dependence of auditory evoked potential (LDAEP) slopes

Jaworska

Blondeau

Tessier

et al. 2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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The loudness-dependence of the auditory evoked potential (LDAEP) slope may be inversely related to serotonin (5-HT) neurotransmission. Thus, steep LDAEPs tend to predict a positive response to selective serotonin reuptake inhibitor (SSRI) antidepressants, which augment 5-HT. However, LDAEPs also predict outcome to antidepressants indirectly altering 5-HT (e.g. bupropion). Hence, the LDAEP’s predicative specificity and sensitivity to antidepressant response/outcome remains elusive. Scalp N1, P2 and N1/P2 LDAEP slopes and standardized low resolution brain electromagnetic tomography (sLORETA)-localized N1 and P2 LDAEP slopes were assessed in depressed individuals (N=51) at baseline, 1 and 12 weeks post-treatment with one of three antidepressant regimens [escitalopram (ESC) + bupropion (BUP), ESC or BUP]. Clinical response was greatest with ESC+BUP at week 1. Treatment responders had steep N1 sLORETA-LDAEP baseline slopes while non-responders had shallow ones. P2 sLORETA-LDAEP slope increases at 1 week existed in responders; decreases were noted in non-responders. Exploratory analyses indicated that more BUP and ESC responders versus non-responders had steep baseline N1 sLORETA-LDAEP slopes. Additionally, slight decreases in scalp P2 LDAEP by week 1 existed for ESC treatment, while slope increases existed with ESC+BUP treatment. Only baseline N1 sLORETA-LDAEP discriminated treatment responders/non-responders. This work confirms that certain LDAEP measures are associated with treatment outcome and appear to be differentially modulated with varying antidepressant drug regimens, though this should be confirmed using larger samples.

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“…LDAEP has been identified to be inversely associated with central nervous system serotonergic activity4, and has been proposed as a reliable indicator of central serotonin activity in humans5. In clinical studies, Fitzgerald et al 6. reported that MDD patients with melancholic features (i.e., lack of mood reactivity) had a significantly weaker LDAEP slope, whereas our previous study showed stronger LDAEP values in atypical depression7.…”

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confidence: 46%

Auditory evoked potential could reflect emotional sensitivity and impulsivity

Kim

Jung

et al. 2016

Sci Rep

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Emotional sensitivity and impulsivity could cause interpersonal conflicts and neuropsychiatric problems. Serotonin is correlated with behavioral inhibition and impulsivity. This study evaluated whether the loudness dependence of auditory evoked potential (LDAEP), a potential biological marker of central serotonergic activity, could reflect emotional sensitivity and impulsivity. A total of 157 healthy individuals were recruited, who performed LDAEP and Go/Nogo paradigms during electroencephalogram measurement. Barratt impulsivity scale (BIS), Conners’ Adult ADHD rating scale (CAARS), and affective lability scale (ALS) were evaluated. Comparison between low and high LDAEP groups was conducted for behavioural, psychological, and event-related potential (ERP) measures. The high LDAEP group showed significantly increased BIS, a subscale of the CAARS, ALS, and false alarm rate of Nogo stimuli compared to the low LDAEP group. LDAEP showed significant positive correlations with the depression scale, ALS scores, subscale of the CAARS and Nogo-P3 amplitude. In the source activity of Nogo-P3, the cuneus, lingual gyrus, and precentral gyrus activities were significantly increased in the high LDAEP group. Our study revealed that LDAEP could reflect emotional sensitivity and impulsivity. LDAEP, an auditory evoked potential could be a useful tool to evaluate emotional regulation.

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A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression

Cited by 48 publications

References 16 publications

Serum BDNF Levels in Relation to Illness Severity, Suicide Attempts, and Central Serotonin Activity in Patients with Major Depressive Disorder: A Pilot Study

Serum BDNF Levels in Relation to Illness Severity, Suicide Attempts, and Central Serotonin Activity in Patients with Major Depressive Disorder: A Pilot Study

Response prediction to antidepressants using scalp and source-localized loudness dependence of auditory evoked potential (LDAEP) slopes

Auditory evoked potential could reflect emotional sensitivity and impulsivity

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