A Study of Otitis Externa Associated with Malassezia

Shiota, Ryoko; Kaneko, Takamasa; Yano, Hiroaki; Takeshita, Kimiko; Nishioka, Keiko; Makimura, Koichi

doi:10.3314/jjmm.50.109

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…Recently, two interesting studies have been published, one showing that M. slooffiae is abundant in the human external auditory canal (21), and the other showing that M. slooffiae may cause otitis externa (22). In the present study, we showed by the highly accurate techniques of real‐time PCR and rRNA clone library analysis that M. slooffiae is the predominant species in both the external auditory canal and on the sole of the foot.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Malassezia microbiota in the human external auditory canal and on the sole of the foot

Zhang

Tanaka

Tsuboi

et al. 2012

Microbiology and Immunology

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Of the fungal skin microbiota, the lipophilic yeast genus Malassezia predominates at all body sites. Of the members of this genus, M. globosa, M. restricta, and M. sympodialis are the most common on the face, limbs, and trunk. In the present study, the Malassezia microbiotas in the external auditory canal and on the sole of the foot were characterized. M. slooffiae was the most common species in both the external auditory canal and on the sole of the foot, followed by M. restricta. Principal component analysis further revealed that the Malassezia microbiota in the external auditory canal and on the sole of the foot constitute a different cluster from those on the scalp and cheek and in the nasal cavity. Additionally, five new Malassezia phylotypes were detected on the sole of the foot and in the external auditory canal. Our results suggest that a distinctive Malassezia microbiota is present in the external auditory canal and on the sole of the foot, although the clinical significance of this finding remains unknown.

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Section: Discussionmentioning

confidence: 99%

Characterization of Malassezia microbiota in the human external auditory canal and on the sole of the foot

Zhang

Tanaka

Tsuboi

et al. 2012

Microbiology and Immunology

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“…Although Malassezia spp. are of little importance as human ear pathogens, 34 the most important fungal agent of canine otomycosis is M. pachydermatis . Other yeasts are involved far more rarely 2,5–17 .…”

Section: Discussionmentioning

confidence: 99%

Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus

Ghibaudo

Peano

2010

Veterinary Dermatology

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Aspergillus ochraceus, a widely distributed filamentous fungus, was isolated and identified by cytology and culture as the cause of unilateral ceruminous purulent otitis in a 4-year-old male mixed-breed dog. The pathogenic role of the fungal isolate was confirmed by a good response to antifungal therapy and the absence of other pathogens. No underlying diseases were identified and the dog recovered after 3 weeks of therapy with oral itraconazole and topical miconazole.

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“…Shiota et al obtained M. slooffiae from scales from OE patients, and demonstrated that the OE lesions could be cured by antifungals. 49 OE is often associated with SD, and this report suggested that the pathogenesis of SD is also related to that of OE. The molecular analyses of the scales and detritus collected from pomade crust, called "Akatsuki disease" in Japanese patients, revealed that M. obtusa and M. slooffiae were the only species present.…”

Section: Seborrheic Dermatitismentioning

confidence: 75%

“…Shiota et al . obtained M. slooffiae from scales from OE patients, and demonstrated that the OE lesions could be cured by antifungals . OE is often associated with SD, and this report suggested that the pathogenesis of SD is also related to that of OE.…”

Section: Seborrheic Dermatitismentioning

confidence: 82%

Malassezia species and their associated skin diseases

Harada

Saito

Sugita

et al. 2015

The Journal of Dermatology

120

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Malassezia spp. are lipophilic fungi that occur on all skin surfaces of humans and animals as commensal and pathogenic organisms. In the 2000s, several new species were added to the Malassezia genus by Japanese researchers. The genus Malassezia now includes 14 species of basidiomycetous yeast. Culture-independent molecular analysis clearly demonstrated that the DNA of Malassezia spp. was predominantly detected in core body and arm sites, suggesting that they are the dominant fungal flora of the human body. Malassezia spp. have been implicated in skin diseases including pityriasis versicolor (PV), Malassezia folliculitis (MF), seborrheic dermatitis (SD) and atopic dermatitis (AD). While Malassezia spp. are directly responsible for the infectious diseases, PV and MF, they act as an exacerbating factor in AD and SD. The fatty acids generated by Malassezia lipase can induce inflammation of the skin, resulting in development of SD. Patch and serum immunoglobulin E tests revealed that AD patients were hypersensitive to Malassezia. However, these findings only partially elucidated the mechanism by which Malassezia spp. induce inflammation in the skin; understanding of the pathogenetic role of Malassezia spp. in SD or AD remains incomplete. In this article, the latest findings of Malassezia research are reviewed with special attention to skin diseases.

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A Study of Otitis Externa Associated with Malassezia

Cited by 11 publications

References 14 publications

Characterization of Malassezia microbiota in the human external auditory canal and on the sole of the foot

Characterization of Malassezia microbiota in the human external auditory canal and on the sole of the foot

Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus

Malassezia species and their associated skin diseases

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