A study of prescribing pattern of antihypertensive drugs in hypertensive patients with co morbid diabetes in a tertiary care teaching hospital

Sharma, Jay Kumar; Parmar, Shailesh P.; Trivedi, Hiren R.

doi:10.18203/2319-2003.ijbcp20180486

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…In antihypertensive multi drug regimen, two drugs regimen was the commonest in this study 57.54% (n=61). These findings are in consonance with other study performed by Sharma JK et al, 38.43% were two drug regimen therapy 3 . Among two drug regimen CCB+ Diuretics combination are generally prescribed.…”

Section: Who Prescribing Indicators?supporting

confidence: 93%

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Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study

Nyamagoud

Swamy

et al. 2022

J. Drug Delivery Ther.

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Background: Hypertension is one of the most frequently occurring noncommunicable diseases, and it causes a variety of cardiovascular complications and mortality. Diagnosis and treatment in elderly patients are very difficult due to their changes in physiology and physiological responses to the therapy. Drug utilization studies are plausible instrument in the evaluation in health care practice. Objective: To assess drug utilization pattern and rational use of antihypertensive therapy in geriatric patients. Materials and methods: This is a prospective observational study that took place in 200 inpatients over the course of six months. The study includes subjects with age group of 65 years and above with all comorbidities. The collected data was statistically evaluated by appropriate descriptive statistical analysis. Here the prescription pattern and rationality were analysed. Results: In this study out of 200 patients, 53% of prescriptions contain combination therapy and remaining 47% contains mono therapy. Most commonly prescribed class as mono therapy was Calcium channel blockers 79. 00% (Amlodipine). Among two drug regimen Calcium channel blockers + Diuretics and the three-drug regimen Calcium channel blockers + Angiotensin Receptor Blocker + Diuretic combination are generally prescribed. Here the overall rate of adherence to JNC 8 is 95%. Conclusion: In this study by analysing prescription pattern, we concluded that most commonly prescribed drug class was Calcium channel blockers (Amlodipine). The present study results demonstrate that, most of the physicians are adherent to the JNC 8 recommendations. Keywords: Antihypertensive drugs, Adherence to JNC 8, Rational use, Prescription patterns.

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Section: Who Prescribing Indicators?supporting

confidence: 93%

“…These findings indicating disparities with study done by Sharma JK et al in small extent. In that BBs are the third most common class (5.48%) and atenolol was the commonest prescribed drug 3 . In antihypertensive multi drug regimen, two drugs regimen was the commonest in this study 57.54% (n=61).…”

Section: Who Prescribing Indicators?mentioning

confidence: 99%

Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study

Nyamagoud

Swamy

et al. 2022

J. Drug Delivery Ther.

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“…The study was conducted at a tertiary care hospital in Kannur to assess the prescription pattern and quality of life in hypertensive patients. A similar study on the prescription pattern of anti-hypertensives was done by Rajeev Mishra et al, 1 Chandra S et al, 2 Chandra Narayan Gupta et al, 3 Shruti Chandra et al, 2 Jay Kumar Sharma et al 4 and Vijayakumar Krishnapillai et al 5 a review article was done by Noah Jarari et al 6 There are studies based on the quality of life based on hypertensive patients by Nandikol Sunanda P et al 7 and Dr K. Mahitha Reddy et al, 8 Baibing Mi et al, 9 Erwei Zheng et al, 10 Sattanathan Kaliyaperumal et al 11 A total of 174 patients were included in the study who satisfied both inclusion criteria and exclusion criteria for a period of 6 months. From the study population of about 174 patients, 111 were males, and 63 were females.…”

Section: Discussionmentioning

confidence: 63%

A Study on Assessment of Prescription Pattern and Quality of Life in Hypertensive Patients in a Tertiary Care Hospital

TM¹

2023

Ind. J. Pharm. Pract.

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Aim:The study aims to assess the prescription pattern and quality of life in hypertensive patients in a tertiary care hospital. Materials and Methods: A prospective observational study of a six-month duration was conducted. All the data were documented and analyzed based on a standard protocol and entered into Microsoft Excel. Quality of life was collected using World Health Organization Quality of Life (WHOOQL)-BREF Questionnaire. The statistical analysis was done by IBM Statistical Package for the Social Sciences (SPSS) Statistics Version 28.0.0.0. Results: A total of 174 hypertensive patients consisting of 111 males and 63 females of age group 32-88 years were included in the study. The study showed Hypertension (HTN) was commonly affected in males. It was further clarified that Stage 2 HTN was the most prevalent one. The patients have been prescribed a total of 9 categories of anti-hypertensives in which the most commonly prescribed anti-hypertensives were diuretics (66.06%) and the least prescribed were alpha (α)-blockers (1.74%) and central sympatholytic (1.74%). Quality of Life (QOL) of hypertensive patients was carried out using the WHOQOL-BREF questionnaires. The comparison shows that a high mean score is seen in the psychological domain and a low mean score is seen in the social health domain. Conclusion: The study provides an overall layout regarding the prescription pattern and QOL in hypertensive patients. The patients were administered a total of 9 categories of anti-hypertensives. From the study, it was concluded that diuretics were the most prescribed anti-hypertensive drug. The average QOL in hypertensive patients were observed more in the psychological health domain (46.19).

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“…15 Another study from Sharma JK et al, reported that ACEIs (85.36%) were the most common drugs for HTN treatment in T2DM. 16 These studies suggest that ACEIs or ARBs remain the first-choice agent in HTN with T2DM. The JNC-8 guidelines also recommend these drugs as first choice agents in patients of HTN with T2DM.…”

Section: Concomitant Drugsmentioning

confidence: 99%

“…Contrasting to this, Sharma et al reported beta-blockers (33.44%) as second most frequently prescribed drugs followed by calcium channel blockers (29.95%). 16 This suggest the choice of second drug might vary in different regions of India depending on the local practices and preferences of physicians and patients.…”

Section: Concomitant Drugsmentioning

confidence: 99%

Prescription pattern and rationality of antihypertensive drugs in patients of type 2 diabetes with hypertension: a pilot study

2019

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Background: As presence of hypertension (HTN) in type 2 diabetes significantly increases risk of morbidity and mortality, its control with rational use of antihypertensives is essential. Authors performed this study to understand the current prescribing pattern of antihypertensives in patients of type 2 diabetes and their assess the rationality to recommendations of JNC-8 guidelines.Methods: Authors performed a cross sectional survey of prescription of diagnosed patients of diabetes with HTN at a tertiary care hospital. Prescription of patients attending medicine OPD were scanned. Data was collected over 2 month and analyzed with descriptive statistics.Results: In 76 patients analysed, mean age was 54.9±9.3 years and 51.3% were females. Insulin and oral antidiabetic agents were prescribed in 16 (21.1%) and 73 (96.1%) patients respectively. One, two, three and four antihypertensive drugs were prescribed in 44 (57.9%), 28 (36.8%), 3 (3.9%) and 1 (1.3%) patients respectively and 24 (31.6%) of them were fixed dose combinations. Among antihypertensives, angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), thiazide diuretics, beta blockers (BBs) and calcium channel blockers (CCBs) were present in 29 (38.2%), 26 (34.2%), 22 (28.9%), 21 (27.6%) and 14 (18.4%) respectively. In individual drugs, ramipril (28.9%) was most common followed by telmisartan (26.3%), hydrochlorothiazide (26.3%), atenolol (16, 21.1%) and amlodipine (17.1%) were frequently prescribed. In adjuvant drugs, antiplatelet (52.6%) and statins (56.6%) were common. This pattern of prescription was as per the recommendations of recent JNC-8 guidelines for treatment of hypertension.Conclusions: ACEIs/ARB are the most preferred for HTN treatment in type 2 diabetes mellitus. Prescription of antihypertensives in our set up was rational as per JNC-8 recommendations.

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A study of prescribing pattern of antihypertensive drugs in hypertensive patients with co morbid diabetes in a tertiary care teaching hospital

Cited by 4 publications

References 10 publications

Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study

Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study

A Study on Assessment of Prescription Pattern and Quality of Life in Hypertensive Patients in a Tertiary Care Hospital

Prescription pattern and rationality of antihypertensive drugs in patients of type 2 diabetes with hypertension: a pilot study

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