A study of relationship between vitamin b12 levels and neurological function in patients with cervical spondylotic myelopathy

Ghumare, Sushant; Chandanwale, Ajay; Jadhav, Pradeep; Arya, Samarth; Rawat, Surendra; Sankar, Suraj

doi:10.22271/ortho.2020.v6.i2j.2109

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“… Risk difference of selected cross-sectional, cohort and retrospective investigations represented on a forest plot after their meta-analysis, in which the noticeable impact of Vitamin B12 interventions compared to their negative to negligible impact was assessed (where the blue dot represents the study with the most weight and the rhombus represents the total weight of the forest plot) [ 14 , 23 , 24 , 25 , 30 ]. …”

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confidence: 99%

Neurological Implications of Vitamin B12 Deficiency in Diet: A Systematic Review and Meta-Analysis

et al. 2023

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Background: Vitamin B12 is one of the most important B-Vitamins that the human body needs on a daily basis, the lack of which can precipitate several neurological issues. Objectives: This systematic aimed to investigate the neurological implications of Vitamin B12 deficiency and the effects when B12 levels were corrected in susceptible individuals. Methods: The databases PubMed-MEDLINE, Web of Science, Cochrane, and Scopus were all searched using pertinent keywords, reference searches, and citation searches. The terms used to access the database were “Cognition”, “Dietary patterns”, “Neurology”, “Nutritional profile”, and “Vitamin B12”. Results: Vitamin B12 was shown to noticeably improve cognition and other neurological parameters in the short term in older adults and the short-to-medium term in children; however, there was no perceived increase/improvement when the Vitamin was administered in the longer term, either alone or in conjunction with other similar nutritional interventions. Conclusion: Vitamin B12’s role in the improvement of neurological functions over a long-term period remains somewhat inconclusive to date, as the majority of our selected control trials did not display much correlation between the two factors. However, Vitamin B12 did improve cognition levels in both children and older adults over a short course of administration.

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