A study of safflower seed extracts on bone formation in vitro

Lee, Seong-Jin; Choi, Ho-Chul; Sun, Ki-Jong; Song, Jeong‐Hoon; Pi, Sung-Hee; You, Hyung‐Keun; Shin, Hyung‐Shik

doi:10.5051/jkape.2005.35.2.461

Cited by 3 publications

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“…29) We have also studied some herbal medicines both in vitro and in vivo in relation to regenerative medicine in periodontal and bone tissues. 22,30) This study confirms that ABM-MSCs exhibit phenotypic features similar to stem cells derived from long bones. 14,31) By analyzing the stages of MSC differentiation, it was shown that DR DM induced increases in ALP activity, calcium accumulation, and BSP and OC expression.…”

Section: Discussionsupporting

confidence: 72%

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells

Kim

Zadeh

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionsupporting

confidence: 72%

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells

Kim

Zadeh

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…In Korea, the safflower seed extracts have traditionally been used for the treatment of blood stasis, the promotion of bone formation and the prevention of osteoporosis [ 23 ]. Safflower seeds might also have a potentiality to use as a drug for bone regeneration [ 24 ], Ob mineralization [ 25 ] and regeneration of periodontal defect [ 26 ]. In addition, safflower seeds have a protecting effect on bone loss caused by estrogen deficiency without substantial effect on the uterus [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Mineral Content in Methanolic Safflower (Carthamus tinctorius L.) Seed Extract and Its Effect on Osteoblast Markers

Lee

Choi

Kim

et al. 2009

IJMS

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Safflower (Carthamus tinctorius L.) seeds are used as a folk medicine to enhance bone formation or to prevent osteoporosis in Korea. Therefore, the methanolic extract of safflower seeds (MESS) containing high mineral content, such as calcium (Ca), potassium (K) and phosphorous (P), was evaluated for the role on osteoblast (Ob) markers of Sprague-Dawley rats. In serum of 3 to 11 weeks (wks) old rats, both osteocalcin (OC) content and bone-specific alkaline phosphatase (B-ALP) activity increased to their maximum levels in 4-7 wks. Hence, 3 wks old rats were selected for 8 wks oral treatment of MESS, resulted in the significant increase of Ob markers in serum such as OC content (4-8 wks), B-ALP activity (1-2 wks) and insulin-like growth factor I (IGF-I) level (1 wk), and the growth parameter such as the length of femur (2-8 wks) and tibia (4 wks). On the basis of Pearson's correlation coefficient, there were a moderate correlation between OC and B-ALP at 8 wks, a low correlation between OC and IGF-I at OPEN ACCESSInt. J. Mol. Sci. 2009, 10 293 1, 4 and 8 wks, a moderate correlation between OC and femur length at 1, 2 and 8 wks, and a moderate correlations between OC and tibia length at 1 and 8 wks of MESS-treated groups. The result reveals that the changes of OC correlated at low to moderate level with the changes of B-ALP activity, IGF-I content and femur and tibia length in the MESStreatment period. On the other hand, there were a strong correlation between IGF-I and femur length at 2 wks and moderate correlation between IGF-I and tibia length at 1, 2 and 8 wks of MESS-treated groups. Therefore, the effect of MESS on bone formation likely appears to be mediated by IGF-I at the early stage of treatment.

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Promotion Effects of Yeast Hydrolysates and a Mixture of Safflower Seed and Gasiogapi Extract on Longitudinal Bone, Proximal Epiphysis, and Growth Hormone in Rats

Lee¹,

Noh

Suh³

2011

JFN

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A study of safflower seed extracts on bone formation in vitro

Cited by 3 publications

References 0 publications

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells

Determination of Mineral Content in Methanolic Safflower (Carthamus tinctorius L.) Seed Extract and Its Effect on Osteoblast Markers

Promotion Effects of Yeast Hydrolysates and a Mixture of Safflower Seed and Gasiogapi Extract on Longitudinal Bone, Proximal Epiphysis, and Growth Hormone in Rats

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