A Study of Some Biochemical Indicators of Kidney Function and Estimation of Some Elements Concentration in the Blood Serum of Patients With Celiac Disease

Abstract

Celiac disease is a long-term autoimmune and digestive disorder that damages small intestine. The current study aimed to estimate some important enzymatic and biochemical variables for kidney functions in patients who eat gluten and abstain from it, compare them with healthy ones, see the usefulness of the GFD “Gluten free diet” to improve the health status of patients, and find biomarkers that contribute to the early diagnosis of celiac disease. The current study was conducted in Nineveh Governorate on patients who came to Al-Salam, Ibn Sina and Al-Khansa Hospital, as well as some private laboratories, as well as some patients from the students of Mosul University, the Technical Institute, and Al-Jada’a and Salamiyah camps after accurate diagnosis by specialist Doctors . 183 blood serum samples were collected for people of both sexes, aged between (2-25) years,. The samples were distributed into three groups, the group of patients who take gluten, including (62) samples (31 males and 31 females), and the group of patients who abstain from eating gluten, which includes (61) samples (31 males and 30 females), as well as the healthy group (control). It includes (60) samples (30 males and 30 females) The results of the current study showed a significant increase in tissue transglutaminase tTG-IgA enzyme for patients taking gluten compared to healthy subjects and no significant difference in enzyme activity in GFD patients compared to healthy subjects at a probability level (p ≤ 0.05). The results also showed that there was no significant difference in the measurement of creatinine, uric acid and glucose in patients who eat gluten as well as for gluten free diet GFD patients, and a significant increase in the measurement of urea in patients who take gluten compared with the healthy group , and no significant difference in the measurement of urea for GFD patients compared with control. The results also showed a significant decrease in Fe+2, Cu+2, Ca+2, and Zn+2 in patients who take gluten, as well as for GFD patients, compared with healthy subjects at a probability level (p ≤ 0.05). In conclusion monitoring of these biochemical markers is important in diagnosis and follow-up of celiac patients.