A study of some practical aspects of high temperature liquid chromatography in pharmaceutical applications

Berta, Renáta; Babják, M; Gazdag, M.

doi:10.1016/j.jpba.2010.09.012

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…Berta et al [101] studied the chromatographic behavior of levonogestrel, a steroid active pharmaceutical ingredient (API) and its impurities using a Zr-CarbonC18 column and methanol:water mobiles phases over a temperature ranges from 50 to 150 C. The upper limit of 150 C was chosen based on the thermal stability of the API. A decrease in retention was observed with increasing both temperature and methanol content.…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Developments in Fast Liquid Chromatographic Analysis of Pharmaceuticals

Natishan

2011

Journal of Liquid Chromatography & Related Technologies

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& The need for pharmaceutical analytical laboratories to increase sample throughput and speed of analysis to meet accelerated drug development timelines has led to considerable interest in the development of fast liquid chromatographic technology. Fast liquid chromatographic pharmaceutical analysis is accomplished by developments in ultra-fast high performance liquid chromatographic instrumentation, emerging technologies in column stationary phases and high temperature liquid chromatographic analysis. This review provides an overview and gives recent developments and applications in the different strategies used in fast liquid chromatographic pharmaceutical analysis.

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Section: Pharmaceutical Applicationsmentioning

confidence: 99%