A study of Spirometric parameters in non asthmatic allergic rhinitis

Thayyezhuth, Devika; Venkataram, Rajesh; Bhat, Vadisha Srinivas; Aroor, Rajeshwary

doi:10.1016/j.heliyon.2021.e08270

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…The asthma control questionnaire (ACQ) is the most widely used standardized questionnaire for asthma control and can evaluate the control degree of patients stably and effectively ( 36 – 38 ). The FEV1 reversibility is a marker of airway hyper-responsiveness (AHR) and has traditionally been considered positively correlated with the severity of asthma ( 39 , 40 ). A combined analysis of two key indicators, i.e., ACQ control and FEV1 reversibility, found that patients with the C1 subtype had higher FEV1 reversibility and more severe poor asthma control than those with the C2 subtype ( Figure 2D ).…”

Section: Resultsmentioning

confidence: 99%

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

et al. 2022

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BackgroundAutophagy has been proven to play an important role in the pathogenesis of asthma and the regulation of the airway epithelial immune microenvironment. However, a systematic analysis of the clinical importance of autophagy-related genes (ARGs) regulating the immune microenvironment in patients with asthma remains lacking.MethodsClustering based on the k-means unsupervised clustering method was performed to identify autophagy-related subtypes in asthma. ARG-related diagnostic markers in low-autophagy subtypes were screened, the infiltration of immune cells in the airway epithelium was evaluated by the CIBERSORT, and the correlation between diagnostic markers and infiltrating immune cells was analyzed. On the basis of the expression of ARGs and combined with asthma control, a risk prediction model was established and verified by experiments.ResultsA total of 66 differentially expressed ARGs and 2 subtypes were identified between mild to moderate and severe asthma. Significant differences were observed in asthma control and FEV1 reversibility between the two subtypes, and the low-autophagy subtype was closely associated with severe asthma, energy metabolism, and hormone metabolism. The autophagy gene SERPINB10 was identified as a diagnostic marker and was related to the infiltration of immune cells, such as activated mast cells and neutrophils. Combined with asthma control, a risk prediction model was constructed, the expression of five risk genes was supported by animal experiments, was established for ARGs related to the prediction model.ConclusionAutophagy plays a crucial role in the diversity and complexity of the asthma immune microenvironment and has clinical value in treatment response and prognosis.

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Section: Resultsmentioning

confidence: 99%

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

et al. 2022

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“…This finding indicated that two pyroptosis-related molecular subtypes (C1 and C2) are observed in asthma. FEV1 reversibility, a marker of airway hyperresponsiveness (AHR), is positively correlated with the severity of asthma ( 35 , 36 ). The asthma control questionnaire (ACQ) is a widely used standardized questionnaire of asthma control that can stably and effectively evaluate the degree of control in patients ( 37 – 39 ).…”

Section: Resultsmentioning

confidence: 99%

Identification of pyroptosis-related subtypes and establishment of prognostic model and immune characteristics in asthma

et al. 2022

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BackgroundAlthough studies have shown that cell pyroptosis is involved in the progression of asthma, a systematic analysis of the clinical significance of pyroptosis-related genes (PRGs) cooperating with immune cells in asthma patients is still lacking.MethodsTranscriptome sequencing datasets from patients with different disease courses were used to screen pyroptosis-related differentially expressed genes and perform biological function analysis. Clustering based on K-means unsupervised clustering method is performed to identify pyroptosis-related subtypes in asthma and explore biological functional characteristics of poorly controlled subtypes. Diagnostic markers between subtypes were screened and validated using an asthma mouse model. The infiltration of immune cells in airway epithelium was evaluated based on CIBERSORT, and the correlation between diagnostic markers and immune cells was analyzed. Finally, a risk prediction model was established and experimentally verified using differentially expressed genes between pyroptosis subtypes in combination with asthma control. The cMAP database and molecular docking were utilized to predict potential therapeutic drugs.ResultsNineteen differentially expressed PRGs and two subtypes were identified between patients with mild-to-moderate and severe asthma conditions. Significant differences were observed in asthma control and FEV1 reversibility between the two subtypes. Poor control subtypes were closely related to glucocorticoid resistance and airway remodeling. BNIP3 was identified as a diagnostic marker and associated with immune cell infiltration such as, M2 macrophages. The risk prediction model containing four genes has accurate classification efficiency and prediction value. Small molecules obtained from the cMAP database that may have therapeutic effects on asthma are mainly DPP4 inhibitors.ConclusionPyroptosis and its mediated immune phenotype are crucial in the occurrence, development, and prognosis of asthma. The predictive models and drugs developed on the basis of PRGs may provide new solutions for the management of asthma.

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Management of Allergic Asthma with Shrishadi Agad followed by Amalaki Rasayana as Add on Treatment

Sharma,

Kajaria

2022

Ayuhom

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Allergic asthma (AA) is the most common form of asthma. An allergy is when the immune system mistakes a harmless substance, such as pollen, dust, and mites. The body releases chemicals to attack the substance and can lead to asthma symptoms such as wheezing, chest tightness, difficulty in breathing, and coughing that can vary over time. A 23-year-old female was diagnosed with AA since 2011 by an allopathic consultant in Delhi. She was regularly treated with short-acting bronchodilators (Levalbuterol) inhaler. Shrishadi Agad is a formulation described in the textbook of Shusruta Samhita which contains Shirish Chaal (Albizia lebbeck), Trikatu Churna, Madhu (∼Honey), and Saindhava lavan (∼Rock salt) which are in totality responsible for its Vishaghna (Anti-toxic) properties. The patient was considered suffering from Santamak Shwasa (∼AA) on the bases of International Classification of Diseases (ICDs)-11 and was treated with Shrishadi Agad twice a daily along with Haritaki Churna, bedtime for 1 month followed by Amalaki Rasayan in the dose of 3 g, twice a day for 2 months. On the basis of the same medication, regular follow-up was taken up to assess the health of the patient. After 3 months of treatment, the patient showed significant improvement in sneezing, breathlessness, cough, and generalized weakness. There is a significant decrease in the range of immunoglobulin E (from 3000 IU/ml to 1493 IU/ml), absolute eosinophil count (from 720/cu.mm. to 228/cu.mm.), and pulmonary parameters (i.e., forced expiratory volume in and forced vital capacity) also shows respective changes. This case shows that Shrishadi agad followed by Amalaki Rasayana is effective in the management of AA on the basis of ICD-11 diagnostic criteria AA modern and Ayurvedic diagnostic criteria.

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A study of Spirometric parameters in non asthmatic allergic rhinitis

Cited by 4 publications

References 14 publications

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

Identification of pyroptosis-related subtypes and establishment of prognostic model and immune characteristics in asthma

Management of Allergic Asthma with Shrishadi Agad followed by Amalaki Rasayana as Add on Treatment

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