A Study of Th2 and Th1 cell Infiltration of the Inferior Turbinate Membrane in Allergic Rhinitis with Deviated Nasal Septum.

Abstract

Purpose : Inferior turbinates chemosurgery with trichloroacetic acid TCA has been assessed histopathologically in allergic rhinitis by comparing bilateral inferior turbinates with both sides treated by turbinectomy and only the deviation free side treated with TCA due to a deviated nasal septum.Because such deviation may influence comparison results, we assessed its influence on Th2 and Th1 cell infiltration of specimens. Subjects : Specimens were bilateral inferior turbinate membranes from 13 subjects with non treated HD allergy. Methods : The two types of cells were counted immunohistochemically per 1mm 2 per specimen. Two way analysis of variance used the deviation and cell type as primary factors. Results : The cell type, but not the deviation factor, was significant at p 0.01. Conclusion : The deviation factor was not related to Th2 or Th1 cell infiltration, but has not been accounted for conventional assessment. Our results confirmed that necessity of the deviation factor need not be considered in assessing TCA treatment efficacy.

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

“…Histologic examination of the treated nasal mucosa showed gradual recovery of its normal function within 1 to 3 years after application without any serious side effects 41,47 . Initially blocked immunological function of the ciliated nasal epithelium was also found gradually recovering 45,48‐55 …”

“…The intranasal application of TCA is of particular interest. TCA has been successfully utilized for chemosurgery of allergic rhinitis for over 25 years 41‐51 . The application of 50% or 80% TCA solution modulates nasal epithelial cells—a docking point of airborne allergens (ie, pollens) and the allergen itself, which leads to significant improvement in nasal obstruction, sneezing, and watery nasal discharge.…”

“…TCA has been successfully utilized for chemosurgery of allergic rhinitis for over 25 years. [41][42][43][44][45][46][47][48][49][50][51] The application of 50% or 80% TCA solution modulates nasal epithelial cells-a docking point of airborne allergens (ie, pollens) and the allergen itself, which leads to significant improvement in nasal obstruction, sneezing, and watery nasal discharge. It was demonstrated to have an indirect positive effect on the lower respiratory tract, influencing the development and modulating the course of allergic asthma.…”

“…41,47 Initially blocked immunological function of the ciliated nasal epithelium was also found gradually recovering. 45,[48][49][50][51][52][53][54][55] This procedure does need to be preceded by anesthesia. A simple rinsing of the treated surface with normal saline was found sufficient to neutralize the TCA and resolve initial burning sensations.…”